目的 研究致康膠囊聯(lián)合甲硝唑栓治療老年性陰道炎的臨床療效。方法 選取2015年4月-2017年4月青海大學(xué)附屬醫(yī)院接收的120例老年性陰道炎患者作為研究對象，將所有患者隨機(jī)分為對照組和治療組，每組各60例。對照組在臨睡前于陰道后穹窿處放置甲硝唑栓，1次/d，0.5 g/次。治療組在對照組治療的基礎(chǔ)上口服致康膠囊，2粒/次，3次/d。兩組患者均連續(xù)治療10 d。觀察兩組的臨床療效，比較兩組的臨床癥狀改善情況、生活質(zhì)量。結(jié)果 治療后，對照組有效率為81.66%，治療組的有效率為96.67%，治療組顯著高于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者陰道灼熱、外陰瘙癢、陰道壁紅腫、白帶增多發(fā)生率均顯著降低，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；并且治療組患者的臨床癥狀改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者軀體功能評分、心理功能評分、物質(zhì)生活評分、社會功能評分和生活質(zhì)量總分均明顯提高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組生活質(zhì)量評分均明顯提高，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 致康膠囊聯(lián)合甲硝唑栓治療老年性陰道炎具有較好的臨床療效，改善臨床癥狀和生活質(zhì)量，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Zhikang Capsules combined with Metronidazole Suppositories in treatment of senile vaginitis. Methods Patients (120 cases) with senile vaginitis in Affiliated Hospital of Qinghai University from April 2015 to April 2017 were randomly divided into control group and treatment group. Each group had 60 cases. Patients in the control group were placed Metronidazole Suppositories on the posterior fornix of the vagina before bedtime, 0.5 g/time, once daily. Patients in the treatment group were po Zhikang Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and quality of life were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.66% and 96.67% respectively, and there were differences between two groups (P<0.05). After treatment, the incidence rates of vaginal heat, vulva itch, vaginal wall redness, and leucorrhea in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the improvements of clinical symptoms in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total scores of physical function, psychological function, material life score, social function and quality of life in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the qualities of life in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zhikang Capsules combined with Metronidazole Suppositories has clinical curative effect in treatment of senile vaginitis, can improve the clinical symptoms and quality of life, which has a certain clinical application value.