目的 探討抗骨增生膠囊聯(lián)合戊酸雌二醇片治療絕經(jīng)后骨質(zhì)疏松癥的臨床療效。方法 選取2016年4月-2017年9月信陽市中心醫(yī)院收治的絕經(jīng)后骨質(zhì)疏松癥患者96例為研究對(duì)象，按照隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各48例。對(duì)照組口服戊酸雌二醇片，1片/次，1次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服抗骨增生膠囊，5粒/次，3次/d。兩組患者均連續(xù)治療6個(gè)月。觀察兩組的臨床療效，比較兩組的骨密度、骨代謝、VAS評(píng)分。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為77.08%、91.67%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組股骨頸、腰椎側(cè)位、wards三角區(qū)、尺橈骨遠(yuǎn)端的骨密度顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組骨密度明顯高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組骨鈣素（BGP）水平顯著升高，堿性磷酸酶（ALP）、Ⅰ型前膠原氨基末端肽（PINP）、Ⅰ型膠原羧基末端肽（CTX）水平顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組骨代謝指標(biāo)明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組VAS評(píng)分明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組VAS評(píng)分明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 抗骨增生膠囊聯(lián)合戊酸雌二醇片治療絕經(jīng)后骨質(zhì)疏松癥具有較好的臨床療效，可改善骨代謝水平，提高骨密度，緩解疼痛，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Kanggu Zengsheng Capsules combined with Estradiol Valerate Tablets in treatment of postmenopausal osteoporosis. Methods Patients (96 cases) with postmenopausal osteoporosis in Xinyang Central Hospital from April 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Estradiol Valerate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Kanggu Zengsheng Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and bone mineral density, bone metabolism, VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.08% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the bone mineral density of femoral neck, lateral lumbar spine, wards triangle, and distal radioulnar in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the bone mineral density indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of BGP in two groups were significantly increased, but the levels of ALP, PINP, and CTX in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the bone metabolism indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kanggu Zengsheng Capsules combined with Estradiol Valerate Tablets has clinical curative effect in treatment of postmenopausal osteoporosis, can improve the level of bone metabolism, increase bone mineral density, and relieve pain, which has a certain clinical application value.