目的 分析西安市中心醫(yī)院質(zhì)子泵抑制劑（PPIs）的使用情況和用藥趨勢，為臨床合理用藥提供參考。方法 調(diào)取2014-2016年西安市中心醫(yī)院PPIs的相關(guān)信息，對品種、用量、銷售金額、用藥頻度（DDDs）、日均費(fèi)用（DDC）及藥品排序比（B/A）進(jìn)行回顧性分析。結(jié)果 PPIs的銷售金額和DDDs總體呈逐年遞增趨勢；銷售金額排名前3位的科室是消化內(nèi)科、普外科和血液科，各科室品種選擇呈逐年多樣化；銷售金額和DDDs連續(xù)3年排第1位的品種分別是注射用蘭索拉唑、雷貝拉唑腸溶片；各品種PPIs的DDC趨于穩(wěn)定；B/A連續(xù)3年為1.00的是注射用泮托拉唑、艾司奧美拉唑腸溶片。結(jié)論 西安市中心醫(yī)院PPIs的應(yīng)用仍存在不合理用藥現(xiàn)象，各部門需加強(qiáng)協(xié)作，提高合理用藥水平，確保患者用藥安全、經(jīng)濟(jì)、有效。

Objective To analyze the situation and developing trend of proton pump inhibitors (PPIs) in Xi'an Central Hospital, and to provide a reference for rational drug use in clinic. Methods Clinical data of PPIs were collected in Xi'an Central Hospital from 2014 to 2016, and the varieties, amount, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed retrospectively. Results Consumption sum and DDDs of PPIs showed an increasing trend year by year. Department with top 3 consumption sum of PPIs were Department of Gastroenterology, General surgery, and Hematology. The variety choice of PPIs was diversified year by year. Consumption sum and DDDs of Lansoprazole Injection and Rabeprazole Enteric-coated Tablets ranked consecutive the first. DDC of PPIs tended to be stable. Pantoprazole for injection and Esomeprazole Enteric-coated Tablets of B/A was 1.00 for three consecutive years. Conclusion The irrational use of PPIs in Xi'an Central Hospital still exists. The departments should strengthen cooperation, raise the level of rational use of PPIs, and ensure the safety, economy and effectiveness of the medication.