膽汁酸主要在肝臟中合成，是膽汁的主要成分之一，其含量和成分的改變與膽固醇結(jié)石形成具有密切關(guān)系。親水性膽汁酸在膽固醇結(jié)石的形成、治療中起重要作用，其具有溶解膽汁中膽固醇并調(diào)節(jié)膽固醇飽和度的重要作用，減少成核異常及保護(hù)并改善膽囊收縮功能的作用。對(duì)親水性膽汁酸對(duì)防治膽固醇結(jié)石形成的作用機(jī)制進(jìn)行綜述。

Bile acids are synthesized from cholesterol in the liver. It's one of the main components of bile, and the change of its content and composition is closely related to the formation of cholesterol gallstones. Hydrophilic bile acids play an important role in cholesterol gallstones' formation and treatment, which have an important role in dissolving cholesterol and regulating the saturation of cholesterol, reducing the abnormal nucleation, protecting and improving the contraction function of the gallbladder. In this paper, the action mechanism of hydrophilic bile acids in prevention and treatment of cholesterol gallstone are reviewed.