目的 探討五黃養(yǎng)陰顆粒聯(lián)合鹽酸吡格列酮治療2型糖尿病的臨床療效。方法 選擇2016年5月-2018年9月在淮安市淮安醫(yī)院治療的2型糖尿病患者96例，根據(jù)用藥的差別分為對(duì)照組（48例）和治療組（48例）。對(duì)照組口服鹽酸吡格列酮片，15~30 mg/次，1次/d；治療組在對(duì)照組基礎(chǔ)上口服五黃養(yǎng)陰顆粒，6 g/次，3次/d。兩組患者均治療8周。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血紅蛋白（HbA1c）、胰島β細(xì)胞功能、超氧化物歧化酶（ROS）、血清尿酸（SUA）和還原型谷胱甘肽（GSH）指標(biāo)。結(jié)果 治療后，對(duì)照組臨床有效率為85.42%，顯著低于治療組的91.67%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，兩組患者空腹血糖FPG、2 h PG、HbA1c等血糖指標(biāo)均明顯降低（P<0.05），且治療組患者這些血糖指標(biāo)比對(duì)照組改善更明顯（P<0.05）。經(jīng)治療，兩組患者FINS水平顯著降低（P<0.05），而ISI指數(shù)和HOMA-IR指數(shù)顯著升高（P<0.05），且治療組患者胰島β細(xì)胞功能明顯好于對(duì)照組（P<0.05）。經(jīng)治療，兩組患者ROS、SUA顯著降低（P<0.05），而GSH顯著升高（P<0.05），且治療組改善程度明顯好于對(duì)照組（P<0.05）。結(jié)論 五黃養(yǎng)陰顆粒聯(lián)合鹽酸吡格列酮片治療2型糖尿病臨床效果良好，降低血糖水平顯著，減輕炎癥反應(yīng)，降低腎臟損傷風(fēng)險(xiǎn)，提高患者生活質(zhì)量。

Objective To investigate the clinical efficiency of Wuhuang Yangyin Granules combined with pioglitazone in treatment of type 2 diabetes. Methods Patients (96 cases) with type 2 diabetes in Huai'an Hospital from May 2016 to September 2018 were divided into control (48 cases) and treatment (48 cases) groups based on different treatments. Patients in the control group were po administered with Pioglitazone Hydrochlorid Tablets, 15-30 mg/time, once daily. Patients in the treatment group were po administered with Wuhuang Yangyin Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and FPG, 2 h PG, HbA1c, islet β cell function, ROS, SUA and GSH in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 85.42%, which was significantly lower than 91.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, FPG, 2 h PG and HbA1c in two groups were significantly decreased, and these glycemic indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the FINS levels in two groups were significantly decreased (P<0.05), but the ISI and HOMA-IR were significantly increased (P<0.05), and the islet β cell function in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the ROS and SUA levels in two groups were significantly decreased, but the GSH levels were significantly increased (P<0.05), and these indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Wuhuang Yangyin Granules combined with pioglitazone in treatment of type 2 diabetes has good clinical effect, can effectively reduce the blood sugar level, reduce the inflammation and the risk of kidney damage, can also improve the quality of life.

R977