目的 了解河南中醫(yī)藥大學(xué)第一附屬醫(yī)院2016-2018年門診抗組胺藥物的使用情況，為臨床合理應(yīng)用提供科學(xué)依據(jù)。方法 采用回顧性研究方法對(duì)2016-2018年河南中醫(yī)藥大學(xué)第一附屬醫(yī)院抗組胺藥物的銷售金額、用藥頻度（DDDs）、日均費(fèi)用（DDC）、排序比（B/A）等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 2016-2018年抗組胺藥物的總金額呈上升趨勢(shì)，占抗變態(tài)反應(yīng)藥總金額的構(gòu)成比浮動(dòng)于50%上下?？菇M胺藥物的品種數(shù)保持不變，均為11種。銷售金額和DDDs整體呈上升趨勢(shì)。第2代抗組胺藥所占銷售金額和DDDs的比例均高，占主導(dǎo)地位。左西替利嗪的銷售金額和DDDs連續(xù)3年穩(wěn)居第1位?？菇M胺藥物的DDC保持相對(duì)穩(wěn)定，左西替利嗪和異丙嗪的B/A為1。結(jié)論 2016-2018年河南中醫(yī)藥大學(xué)第一附屬醫(yī)院門診抗組胺藥物的品種基本能滿足臨床需求，抗組胺藥物的使用量呈上升趨勢(shì)，第2代抗組胺藥是臨床使用的主力軍，與各指南推薦相符，基本合理。

Objective To evaluate the utilization of antihistamine agents in Department of Outpatient in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018. Methods The use of antihistamine agents in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018 were analyzed statistically in terms of consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A), etc. Results Consumption sum of antihistamine drugs maintained an upward trend, and the component ratio of the total amount of antiallergic drugs fluctuated around 50%. The number of antihistamine drugs was remained unchanged with 11. Sales amount and DDDs of antihistamine agents remained on a growth trend. Sales amount and DDDs of the second generation of antihistamine drugs was in the leading position with high constituent ratio. Consumption sum and DDDs of levocetirizine was ranked the first for 3 consecutive years. DDC of antihistamine agents remained relatively stable. B/A of levocetirizine and promethazine were 1. Conclusion The number of antihistamine drugs could meet clinical needs in Department of Outpatient in the First Affiliated Hospital of Henan University of TCM from 2016 to 2018. The use of antihistamines is on the rise. The second generation of antihistamine drugs is the principle force and clinical use is reasonable in the main according with the guidelines.

R976