自2019年12月以來，新型冠狀病毒（SARS-CoV-2）在國內(nèi)爆發(fā)，并且目前已在日本和韓國等地進入高發(fā)態(tài)勢，該病毒導致的新型冠狀病毒肺炎（COVID-19）已造成多人感染并有2 500余人死亡，世界衛(wèi)生組織于2020年1月31日宣布疫情為"國際關注的突發(fā)公共衛(wèi)生事件"。抗新型冠狀病毒藥物是阻止病毒傳播以及在宿主體內(nèi)復制從而引起肺炎的有力武器。綜述了抗COVID-19藥物靶點以及相應的藥物和候選物的研究進展。

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been in the high incidence since December 2019, and has been in high incidence in Japan and Korea. The corona virus disease 2019 (COVID-19) caused by the virus is likely to cause thousands of people infected and more than 2 500 deaths. On January 31, 2020, the World Health Organization declared the epidemic as Public Health Emergency of International Concern. Anti SARS-CoV-2 drugs are powerful weapons to prevent virus transmission and to cause pneumonia in hosts. Herein, the research progress of the anti SARS-CoV-2 drug targets and related drug candidates were summarized in this papaer.

R974

江蘇省基礎研究計劃面上資助項目（BK20181209）