目的 通過大鼠在體單向腸灌流實驗研究黃芩湯中黃芩苷在體腸吸收特性。方法 建立大鼠在體單向腸灌流模型，采用質(zhì)量法計算黃芩苷吸收速率常數(shù)（K_a）和有效滲透系數(shù)（P_eff）。結果 黃芩湯中黃芩苷在十二指腸、空腸、回腸的吸收速率和程度都存在一定差異。其中黃芩苷在十二指腸的吸收速率顯著高于空腸段，差異具有統(tǒng)計學意義（P<0.05），略高于回腸段但差異無統(tǒng)計學意義；黃芩苷在十二指腸的吸收程度明顯高于空腸段且差異具有統(tǒng)計學意義（P<0.05），略高于回腸段但差異無統(tǒng)計學意義。結論 黃芩湯中黃芩苷在十二指腸的吸收速度和吸收程度較好，表明黃芩湯中黃芩苷在體吸收具有腸道部位依賴特性。

Objective To study the intestinal absorption characteristics of baicalin in Huangqin decoction by in vivo single intestinal perfusion test. Methods Rat model of in vivo single intestinal perfusion model was established, and the absorption rate constant (K_a) and effective osmotic coefficient (P_eff) of baicalin were calculated. Results The absorption rate and degree of baicalin in duodenum, jejunum and ileum were significantly different. The absorption rate of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant (P<0.05), and it slightly higher than that in ileum, and the difference was not statistically significant. The absorption degree of baicalin in duodenum was significantly higher than that in jejunum, and the difference was statistically significant (P<0.05), but it slightly higher than that in ileum, and the difference was not statistically significant. Conclusion The absorption rate and degree of baicalin in the duodenum of Huangqin Decoction are good, so it indicates that the absorption of baicalin in Huangqin Decoction has intestinal site-dependent characteristics.

R966

成都中醫(yī)藥大學?；鹎嗄杲處焺?chuàng)新基金（ZRQN1706）；成都中醫(yī)藥大學校基金醫(yī)院專項（2017EL20）