[關鍵詞]
[摘要]
目的 分析龍血通絡聯(lián)合長春西汀注射液治療血栓性腦梗死恢復期的臨床效果。方法 選擇2017年7月-2019年2月鄭州大學第二附屬醫(yī)院收治的143例血栓性腦梗死恢復期患者,隨機分成對照組(71例)和治療組(72例)。對照組靜脈滴注長春西汀注射液,30 mg加入生理鹽水,1次/d。治療組在對照組基礎上口服龍血通絡膠囊,2粒/次,3次/d。兩組患者均治療2周。觀察兩組患者臨床療效,同時比較治療前后兩組患者平均腦血流速度、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL-C)和總膽固醇(TC)水平。結果 治療后,對照組臨床有效率為76.06%,顯著低于治療組的93.06%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組大腦中動脈(MCA)、大腦后動脈(PCA)、大腦前動脈(ACA)、基底動脈(BA)平均血流速度均顯著增加(P<0.05),且治療組平均血流速度明顯高于對照組(P<0.05)。治療后,兩組TG、LDL和TG水平均得到明顯降低(P<0.05),而HDL-C水平明顯升高(P<0.05),且治療組血脂水平均明顯優(yōu)于對照組(P<0.05)。結論 龍血通絡聯(lián)合長春西汀注射液治療腦血栓恢復期患者,可有效改善患者臨床癥狀,促進腦部血液循環(huán),優(yōu)化神經(jīng)功能和血脂水平,具有一定的臨床推廣應用價值。
[Key word]
[Abstract]
Objective To analyze the clinical effect of Longxue Tongluo Capsules combined with Vinpocetine Injection in treatment of thrombotic cerebral infarction at recovery stage. Methods Patients (143 cases) with thrombotic cerebral infarction at recovery stage in the Second Affiliated Hospital of Zhengzhou University from July 2017 to February 2019 were randomly divided into control (71 cases) and treatment (72 cases) groups. Patients in the control group were iv administered with Vinpocetine Injection, 30 mg added into normal saline, once daily. Patients in the treatment group were po administered with Longxue Tongluo Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the average cerebral blood flow velocity, the level of TG, LDL, HDL-C, and TC in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.06%, which was significantly lower than 93.06% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the average cerebral blood flow velocity of MCA, PCA, ACA, and BA in two groups were significantly increased (P<0.05), and these indexes in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the level of TG, LDL, and TG in two groups was significantly decreased (P<0.05), but the level of HDL-C was significantly increased (P<0.05), and the blood lipid level in the treatment group was significantly better than that in the control group (P<0.05). Conclusion Longxue Tongluo Capsules combined with Vinpocetine Injection in treatment of thrombotic cerebral infarction at recovery stage can effectively improve the clinical symptoms, promote cerebral blood circulation, optimize nerve function and blood lipid level, which has a certain clinical application value.
[中圖分類號]
R971
[基金項目]