目的 探討注射用血栓通聯(lián)合瑞舒伐他汀鈣片治療不穩(wěn)定型心絞痛的臨床療效。方法 選取2018年1月-2019年5月天津市寧河區(qū)醫(yī)院收治的86例不穩(wěn)定型心絞痛患者為研究對象，將所有患者按照隨機數(shù)字表法分為對照組和治療組，每組各43例。對照組患者口服瑞舒伐他汀鈣片，10 mg/次，1次/d。治療組患者在對照組治療的基礎(chǔ)上靜脈滴注注射用血栓通（凍干），250 mg/d，1次/d。兩組患者均連續(xù)治療14 d。觀察兩組患者的心絞痛療效和心電圖療效，并比較兩組的臨床癥狀、內(nèi)皮功能因子水平和血脂水平。結(jié)果 治療組心絞痛的總有效率為95.35%，對照組心絞痛的總有效率為81.40%，兩組的心絞痛療效比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療組心電圖的總有效率為88.37%，對照組心電圖的總有效率為69.77%，兩組心電圖療效比較，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組發(fā)作時間、持續(xù)時間、硝酸甘油用量均顯著降低（P<0.05）；治療后治療組患者的發(fā)作時間、持續(xù)時間、硝酸甘油用量比對照組低，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者一氧化氮（NO）高于治療前，內(nèi)皮素1（ET-1）、血管內(nèi)皮細胞鈣黏蛋白（VEC）、血栓素B2（TXB2）低于治療前（P<0.05）；治療后治療組的NO高于對照組，ET-1、VEC、TXB2低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者在治療后的總膽固醇、三酰甘油、低密度脂蛋白膽固醇（LDL-C）水平均明顯降低（P<0.05），且治療后治療組血脂水平比對照組低，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 注射用血栓通聯(lián)合瑞舒伐他汀鈣片治療不穩(wěn)定型心絞痛的療效確切，減輕臨床癥狀，改善血管內(nèi)皮功能和血脂水平，降低不良反應(yīng)的發(fā)生，具有重要臨床研究價值。

Objective To investigate the clinical effect of Xueshuantong Injection combined with Rosuvastatin Calcium Tablets in treatment of unstable angina pectoris. Methods Patients (86 cases) with unstable angina pectoris in Tianjin Ninghe Hospital from January 2018 to May 2019 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 10 mg/time, once daily. Patients in the treatment group were iv administered with Xueshuantong Injection on the basis of the control group, 250 mg/d, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies of angina pectoris and electrocardiogram efficacies were evaluated, and improvement of angina symptoms, endothelial function factor levels, and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies of angina pectoris in the control and treatment groups were 81.40% and 95.35%, and the electrocardiogram efficacies in the control and treatment groups were 69.77% and 88.37%, respectively, and there was difference between two groups (P<0.05). After treatment, the attack time, duration and dosage of nitroglycerin in two groups were significantly decreased (P<0.05). And the attack time, duration and dosage of nitroglycerin in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, levels of NO in two groups were significantly increased, but the levels of ET-1, VEC, and TXB2 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the endothelial function factor levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total cholesterol, triglyceride and LDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xueshuantong Injection combined with Rosuvastatin Calcium Tablets has definite curative effect in the treatment of unstable angina pectoris, can relieve the symptoms of angina pectoris, improve the function of vascular endothelium and blood lipid levels, and reduce the occurrence of adverse reactions, which has important clinical research value.

R972