目的 觀察和分析小兒肺熱清顆粒聯(lián)合頭孢呋辛酯干混懸劑治療小兒急性支氣管炎的臨床療效。方法 選擇2017年8月-2019年2月在北京市順義區(qū)醫(yī)院治療的147例急性支氣管炎患兒，隨機(jī)分為對照組（74例）和治療組（73例）。對照組口服頭孢呋辛酯干混懸劑，0.125 g/次，2次/d。治療組在對照組基礎(chǔ)上口服小兒肺熱清顆粒，1~3歲患兒4 g/次，3~7歲患兒6 g/次，7~12歲患兒8 g/次，3次/d。兩組均治療10 d。觀察兩組患者臨床療效，同時比較治療前后兩組患者血清白細(xì)胞介素-4（IL-4）、超敏C反應(yīng)蛋白（hs-CRP）和腫瘤壞死因子-α（TNF-α）水平及癥狀消失時間。結(jié)果 治療后，對照組和治療組臨床有效率分別為79.73%、93.15%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者血清IL-4、hs-CRP和TNF-α均明顯降低（P<0.05），且治療組IL-4、hs-CRP和TNF-α明顯比對照組低（P<0.05）。治療后，治療組肺部啰音、咳嗽和發(fā)熱消失時間明顯短于對照組（P<0.05）。結(jié)論 小兒肺熱清顆粒聯(lián)合頭孢呋辛酯干混懸劑治療小兒急性支氣管炎，可明顯改善患兒炎癥水平，迅速緩解臨床癥狀，具有較好的治療效果，安全可靠。

Objective To analyze the clinical effect of Xiaoer Feireqing Granules combined with Cefuroxime Axetil for suspension in treatment of acute bronchitis in children. Methods Children (147 cases) with acute bronchitis in Beijing Shunyi District Hospital from August 2017 to February 2019 were randomly divided into control (74 cases) and treatment (73 cases) groups. Children in the control group were po administered with Cefuroxime Axetil for suspension, 0.125 g/time, twice daily. Children in the treatment group were po administered with Xiaoer Feireqing Granules on the basis of the control group, 4 g/time for 1-3 years old children, 6 g/time for 3-7 years old, 8 g/time for 7-12 years old, three times daily. Children in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the serum level of IL-4, hs-CRP, TNF-α, and the time of symptoms disappear in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 79.73% and 93.15%, respectively, and there were differences between two groups (P<0.05). After treatment, the serum level of IL-4, hs-CRP, and TNF-α in two groups was significantly decreased (P<0.05), and the level in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the disappearance time of pulmonary rales, cough and fever in the treatment group was significantly earlier than that in the control group (P<0.05). Conclusion Xiaoer Feireqing Granules combined with Cefuroxime Axetil for suspension in treatment of acute bronchitis in children can significantly improve the inflammatory level and rapidly relieve clinical symptoms, which has good therapeutic effect with high safety and reliability.

R974