目的 探討喜炎平注射液聯(lián)合注射用更昔洛韋治療兒童流行性腮腺炎的臨床療效。方法 選取天津市寶坻區(qū)人民醫(yī)院2017年3月-2019年9月收治的82例流行性腮腺炎患兒作為研究對象，按隨機數(shù)字表法將所有患兒分為對照組和治療組，每組各41例。對照組靜脈滴注注射用更昔洛韋，5 mg/kg，每12小時1次。治療組在對照組治療的基礎上靜脈滴注喜炎平注射液，10 mg/（kg·d）。兩組患兒連續(xù)治療7 d。觀察兩組患者臨床療效，同時比較治療前后兩組患兒臨床癥狀改善情況、疼痛程度和炎性因子水平。結果 治療組總有效率為95.12%，明顯高于對照組80.49%，差異有統(tǒng)計學意義（P<0.05）。治療組的體溫恢復時間、腮腺消腫時間、頸抵抗消失時間、嗜睡消失時間均明顯短于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組患兒的VAS評分明顯低于治療前（P<0.05），以治療組患兒降低的更明顯，差異有統(tǒng)計學意義（P<0.05）。在治療后，兩組患兒的白介素-4（IL-4）、白介素-8（IL-8）、腫瘤壞死因子-α（TNF-α）水平均顯著降低（P<0.05）；治療后治療組的IL-4、IL-8、TNF-α水平比對照組低，差異有統(tǒng)計學意義（P<0.05）。結論 喜炎平注射液聯(lián)合注射用更昔洛韋能有效提高流行性腮腺炎的臨床療效，減輕患兒的臨床癥狀和疼痛程度，抑制炎性因子分泌，具有一定的臨床研究價值。

Objective To investigate the clinical effect of Xiyanping Injection combined with Ganciclovir for injection in treatment of mumps in children. Methods Children (82 cases) with mumps in Tianjin Baodi District People's Hospital from March 2017 to September 2019 were divided into control group (41 cases) and treatment group (41 cases) according to the random number table method. Children in the control group were iv administered with Ganciclovir for injection, 5 mg/kg, once per 12 h. Children in the treatment group were iv administered with Xiyanping Injection on the basis of the control group, 10 mg/(kg·d). Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, degree of pain, and levels of inflammatory factors in two groups were compared. Results The total effective rate in the treatment group (95.12%) was significantly higher than that(80.49%) of the control group (P<0.05). After treatment, the body temperature recovery time, parotid detumescence time, neck resistance disappearance time, and drowsiness disappearance time between two groupsin the treatment group were shorter than those in the control group (P<0.05). After treatment, the VAS scores in two groups were significantly decreased (P<0.05), and the VAS scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-4, IL-8, and TNF-αin two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the levels of IL-4, IL-8, and TNF-αin the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiyanping Injection combined with Ganciclovir for injection can effectively improve the clinical efficacy of mumps in children, relieve the clinical symptoms and pain of children, and inhibit the secretion of inflammatory factors, which has a certain clinical application value.

R974;R985