目的 探討抗感顆粒聯(lián)合帕拉米韋氯化鈉注射液治療兒童流行性感冒的臨床療效。方法 選取2017年5月-2019年5月在資陽(yáng)市第一人民醫(yī)院治療的156例流行性感冒患兒，根據(jù)用藥的差別分為對(duì)照組（78例）和治療組（78例）。對(duì)照組靜脈滴注帕拉米韋氯化鈉注射液，10 mg/kg，1次/d；治療組在對(duì)照組基礎(chǔ)上口服抗感顆粒，10 g/次，3次/d。兩組患者均經(jīng)5 d治療。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者臨床癥候積分及血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、干擾素-γ（IFN-γ）和降鈣素原（PCT）水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為84.62%、98.72%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，兩組癥候積分顯著降低（P<0.05），且治療組比對(duì)照組降低更明顯。經(jīng)治療，兩組患者血清CRP、IL-6、TNF-α、IFN-γ、PCT水平明顯均下降（P<0.05），且治療組患者比對(duì)照組降低更明顯（P<0.05）。結(jié)論 抗感顆粒聯(lián)合帕拉米韋氯化鈉注射液治療兒童流行性感冒可有效改善患兒臨床癥狀，降低機(jī)體炎癥反應(yīng)，增強(qiáng)機(jī)體免疫功能，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical efficacy of Kanggan Granules combined with Peramivir and Sodium Chloride Injection in treatment of influenza in children. Methods Children (156 cases) with influenza in the First People's Hospital of Ziyang from May 2017 to May 2019 were divided into control (78 cases) and treatment (78 cases) groups based on different treatments. Children in the control group were iv administered with Peramivir and Sodium Chloride Injection, 10 mg/time, once daily. Children in the treatment group were po administered with Kanggan Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom score and the serum level of CRP, IL-6, TNF-α, IFN-γ and PCT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 84.62% and 98.72%, respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom score in two groups was significantly decreased (P<0.05), and the score in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum level of CRP, IL-6, TNF-α, IFN-γ, and PCT in two groups was significantly decreased (P<0.05), and the inflammatory factors level in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Kanggan Granules combined with Peramivir and Sodium Chloride Injection in treatment of children influenza can effectively improve the clinical symptoms of children, reduce the body's inflammatory response, and enhance the body's immune function, which has a certain clinical application value.

R985