目的 探討藤黃健骨膠囊聯(lián)合玻璃酸鈉注射液治療膝骨關(guān)節(jié)炎的臨床療效。方法 選取2018年7月-2019年6月在鄭州市骨科醫(yī)院就診的94例膝骨關(guān)節(jié)炎患者作為研究對象，將所有患者按照隨機數(shù)字表法分為對照組和治療組，每組各47例。對照組腔內(nèi)注射玻璃酸鈉注射液，2.0 mL/次，1次/周。治療組在對照組治療的基礎上口服藤黃健骨膠囊，1.0 g/次，2次/d。兩組患者連續(xù)治療5周。觀察兩組患者臨床療效，同時比較治療前后兩組患者膝關(guān)節(jié)功能、疼痛程度和血清炎性因子水平。結(jié)果 治療組的總有效率為91.49%，對照組的總有效率為76.60%；兩組的總有效率比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的Lysholm評分高于治療前，VAS評分明顯低于治療前（P<0.05）；在治療后治療組的Lysholm評分比對照組高，VAS評分低于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的白介素1β（IL-1β）、白介素17（IL-17）、白介素23（IL-23）、胰島素樣生長因子1（IGF-1）水平均明顯低于治療前（P<0.05）；在治療后治療組的IL-1β、IL-17、IL-23、IGF-1水平均比對照組低，差異有統(tǒng)計學意義（P<0.05）。結(jié)論 藤黃健骨膠囊聯(lián)合玻璃酸鈉注射液能提高膝骨關(guān)節(jié)炎的臨床療效，改善關(guān)節(jié)功能，減輕疼痛，降低血清炎性因子水平，具有一定臨床研究價值。

Objective To investigate the clinical effect of Tenghuang Jiangu Capsules combined with Sodium Hyaluronate Injection in treatment of knee osteoarthritis. Methods Patients (94 cases) with knee osteoarthritis in Zhengzhou Orthopedic Hospital from July 2018 to June 2019 were divided into control (47 cases) and treatment (47 cases) groups based on random number table method. Patients in the control group were intraarticular injection of Sodium Hyaluronate Injection, 2.0 mL/time, once weekly. Patients in the treatment group were po administered with Tenghuang Jiangu Capsules on the basis of the control group, 1.0 g/time, twice daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacy was evaluated, and the knee function, degree of pain, and the serum levels of inflammatory factors in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.60%, which was significantly lower than91.49% in the treatment group, and there were differences between two groups (P<0.05). After treatment, Lysholm scores in two groups were significantly increased, but the VAS scores were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the Lysholm scores in the treatment group were significantly higher than those in the control group, but the VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-1β, IL-17, IL-23 and IGF-1 in the two groups were significantly decreased (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Tenghuang Jiangu Capsules combined with Sodium Hyaluronate Injection has clinical curative effect in treatment of knee osteoarthritis, can improve joint function, relieve pain, reduce the level of serum inflammatory factors, which has a certain clinical application value.

R977