目的 了解鄭州市第六人民醫(yī)院應(yīng)用伏立康唑所致藥品不良反應(yīng)（ADR）的特點(diǎn)、一般規(guī)律及預(yù)后，為臨床安全合理使用伏立康唑提供參考。方法 對2018年1~12月使用伏立康唑的162例病例進(jìn)行回顧性分析，共計(jì)54例患者出現(xiàn)不良反應(yīng)，按是否合并艾滋?。ˋIDS）、患者性別、年齡、給藥方式、ADR發(fā)生時(shí)間、累及的器官或系統(tǒng)、轉(zhuǎn)歸等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 54例ADR中，AIDS患者42例，非AIDS患者12例；男性39例，女性15例；41~70歲的有39例。2~5 d內(nèi)發(fā)生ADR的有27例，占50%；不良反應(yīng)以神經(jīng)系統(tǒng)損害最多，其余可涉及肝膽系統(tǒng)、皮膚及其附件、視覺系統(tǒng)等。1例腎損害患者留有后遺癥，其余經(jīng)過停藥或?qū)ΠY處理后均好轉(zhuǎn)。結(jié)論 AIDS患者使用伏立康唑不良反應(yīng)發(fā)生率顯著高于非AIDS患者，臨床在合理用藥的同時(shí)，對AIDS患者尤其應(yīng)加強(qiáng)監(jiān)測。

Objective To analyze the characteristics, general rules, and prognosis of adverse reactions induced by voriconazole in the Sixth People's Hospital of Zhengzhou in 2018, and to provide reference for rational use of voriconazole. Methods A retrospective analysis was conducted on 162 patients who used voriconazole from January to December 2018, and a total of 54 patients had ADR, and the 54 cases were analyzed in terms of whether combined AIDS, sex, age, mode of administration, time of ADR, organs or systems involved, outcome, etc. Results In 54 cases of ADR, there were 42 cases of patients with AIDS, and 12 cases without AIDS. There were 39 cases of male patients and 15 cases of female patients. Most of ADR occurred in patients of 41-70 years old. There were 27 cases of ADR occurred within 2-5 d, accounting for 50%. Mental disorder was the major clinical manifestation, followed by liver damage, skin lesions, and visual impairment, etc. After withdrawal of voriconazole and symptomatic treatment, most of the symptoms disappeared, except one patient with renal injury had sequel. Conclusion The incidence of voriconazole in AIDS patients is higher than others, so the monitoring of AIDS patients should be strengthened on basis of rational use.

R969.3

“十三五”艾滋病和病毒性肝炎等重大傳染病防治科技重大專項(xiàng)（2017ZX10202101-001-010）