目的 了解咸陽市第一人民醫(yī)院抗感染藥物不良反應(yīng)的發(fā)生規(guī)律及特點(diǎn)，為合理使用抗感染藥物提供依據(jù)。方法 對2014-2018年咸陽市第一人民醫(yī)院上報(bào)的162例抗感染藥物所致ADR報(bào)告進(jìn)行整理，從患者年齡、藥品品種、給藥途徑以及臨床表現(xiàn)等方面進(jìn)行歸納分析。結(jié)果 162例ADR中，中老年患者較易發(fā)生ADR，喹諾酮類及頭孢菌素類藥物發(fā)生ADR的例數(shù)最多，引發(fā)ADR的主要給藥途徑為靜脈給藥，ADR主要表現(xiàn)為皮膚及其附件損害。結(jié)論 根據(jù)ADR發(fā)生的規(guī)律和特點(diǎn)，應(yīng)加強(qiáng)抗感染藥物的用藥監(jiān)管力度，重點(diǎn)監(jiān)護(hù)特殊人群用藥，減少ADR的發(fā)生，保障患者安全用藥。

Objective To understand the occurrence regularity and characteristics of adverse reactions of anti-infective drugs in the First People's Hospital of Xianyang, and to provide professional and technical basis for rational use of anti-infective drugs. Methods 162 ADR cases caused by anti-infective drugs reported in the First People's Hospital of Xianyang from 2014 to 2018 were sorted out and analyzed from the aspects of patient's age, drug variety, route of administration, and clinical manifestations. Results Among 162 cases of ADR, middle-aged and elderly patients were more prone to ADR. Quinolones and cephalosporins were the most common types of ADR. Intravenous administration was the main route to induce ADR. ADR was mainly manifested by skin and its appendages damage. Conclusion According to the regularity and characteristics of ADR, the supervision of the use of anti-infective drugs should be strengthened to focus on monitoring the use of drugs in special population and ensure the safe use of drugs for patients.

R969.3