目的 分析2017-2018年天津市寶坻區(qū)人民醫(yī)院萬(wàn)古霉素的使用情況，為促進(jìn)萬(wàn)古霉素的臨床合理使用提供參考。方法 收集天津市寶坻區(qū)人民醫(yī)院2017年1月-2018年12月使用萬(wàn)古霉素的住院患者病歷228例，對(duì)患者基本概況、科室分布、病原學(xué)檢查、給藥劑量、給藥途徑、用藥療程及血藥濃度監(jiān)測(cè)情況等進(jìn)行回顧性統(tǒng)計(jì)分析。結(jié)果 228例患者中，男性（143例，62.72%）多于女性（85例，37.28%）；患者主要分布于骨科（73例，32.02%），神經(jīng)外科（32例，14.04%）等；195例在使用萬(wàn)古霉素前進(jìn)行了病原學(xué)檢查，微生物檢驗(yàn)樣本送檢率為85.53%；檢出的病原菌主要為金黃色葡萄球菌（26例，35.62%），表皮葡萄球菌（15例，20.55%）等；193例（84.65%）為靜脈滴注給藥；給藥劑量主要為2 g/d（156例，68.42%）；144例（63.16%）給藥療程少于7 d；39例（31.70%）行萬(wàn)古霉素血藥濃度監(jiān)測(cè)患者中，血藥谷濃度維持在10~20 mg/L的為15例（38.46%）。結(jié)論 2017-2018年天津市寶坻區(qū)人民醫(yī)院萬(wàn)古霉素總體應(yīng)用基本合理，應(yīng)加強(qiáng)萬(wàn)古霉素的應(yīng)用管理，促進(jìn)其合理使用。

Objective To analyze the clinical use of vancomycin in Tianjin Baodi People's Hospital from 2017 to 2018, and to provide reference for promoting rational use of vancomycin in the clinic. Methods 228 Inpatient medical records of vancomycin were collected from Tianjin Baodi People's Hospital from January 2017 to Decemer 2018. Retrospective method was used to analyze the overview of patients, different departments, pathogenic bacteria examination, administration of dosage, administration of route, course of treatment, and therapeutic drug concentration monitoring of vancomycin. Results Among 228 cases, male (143 cases, 62.72%) was more than female (85 cases, 37.28%). Department of orthopedics (73 cases, 32.02%) and Department of neurosurgery (32 cases, 14.04%) had higher vancomycin usage ratio. 195 Cases of microbiological samples (85.53%) were detected, and main of pathogenic bacteria were Staphylococcus aureus (26 cases, 35.62%) and Staphylococcus epidermidis (15 cases, 20.55%). Among 228 cases, there were 193 cases (84.65%) for intravenous administration, and 156 cases (68.42%) with dosage of 2 g/d, and 144 cases (63.16%) with course of treatment less than 7 d. A total of 39 cases (31.70%) blood drug concentration were monitored and 15 cases trough concentration remained at 10-20 mg/L. Conclusion The use of vancomycin in Tianjin Baodi People's Hospital is basically rational, it's necessary to pay more attentions to serum concentration monitoring to ensure the drug safety of patients.

R969.3