目的 分析南京地區(qū)60家醫(yī)院2016-2018年神經(jīng)系統(tǒng)輔助用藥的使用情況，評價該類藥物在臨床的使用現(xiàn)狀與趨勢。方法 收集2016-2018年南京地區(qū)60家醫(yī)院神經(jīng)系統(tǒng)輔助用藥的使用數(shù)據(jù)，對用藥金額、用藥頻度（DDDs）、日均費用（DDC）和藥品排序比（B/A）進行統(tǒng)計分析。結(jié)果 2016-2018年南京地區(qū)60家醫(yī)院神經(jīng)系統(tǒng)輔助用藥的總銷售金額呈下降趨勢，改善腦代謝類藥物和改善腦循環(huán)類藥物在神經(jīng)系統(tǒng)輔助用藥內(nèi)占主導(dǎo)地位。銷售金額前3位的藥物分別為奧拉西坦、單唾液酸四己糖神經(jīng)節(jié)苷脂鈉和前列地爾，總體呈下降趨勢。DDDs總量呈上升趨勢，其中排名前3位的藥物有胞磷膽堿、血塞通和前列地爾。DDC排名前3位的藥物為依達拉奉、單唾液酸四己糖神經(jīng)節(jié)苷脂鈉和鼠神經(jīng)生長因子。0.5 ≤ B/A ≤ 1.5的品種有18、17、16種；DDC排名前3的藥物為依達拉奉、單唾液酸四己糖神經(jīng)節(jié)苷脂鈉和鼠神經(jīng)生長因子。結(jié)論 南京地區(qū)60家醫(yī)院神經(jīng)系統(tǒng)輔助用藥的使用基本合理，且各類藥物的使用基本呈下降趨勢。

Objective To analyze the utilization of nervous system auxiliary drugs in 60 hospitals in Nanjing area from 2016 to 2018, and in order to evaluate the status quo and trends of nervous system auxiliary drugs. Methods The data of nervous system auxiliary drugs in 60 hospitals from Nanjing area from 2016 to 2018 were collected, and consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2016 to 2018, the total sales of nervous system auxiliary drugs in 60 hospitals in Nanjing area were on a declining curve. Drugs that improve brain metabolism and improve brain circulation were dominated in nervous system auxiliary drugs. Consumption sum of oxiracetam, tetrahexosaccharide monosalic acid ganglioside sodium, and alprostadil were ranked for the top three. The overall trend was downward. DDDs had the trend of increase, in which DDDs of citicoline, xuesetong, and alprodil were ranked for the top three. There were 18, 17, and 16 species of drugs with B/A between 0.5 and 1.5. DDC of edaravone, tetrahexyl monosialic acid ganglioside sodium, and rat nerve growth factor were ranked for the top three. Conclusion The use of nervous system auxiliary drugs in 60 hospitals in Nanjing area from 2016 to 2018 is basically reasonable, and the use of various drugs show a decreasing trend.

R971