目的 分析2016-2019年淮南新華醫(yī)療集團(tuán)新華醫(yī)院新生兒科重癥監(jiān)護(hù)室感染性疾病病原菌的分布及耐藥性。方法 回顧性分析2016年1月-2019年4月淮南新華醫(yī)療集團(tuán)新華醫(yī)院新生兒科重癥監(jiān)護(hù)室的病原菌分布情況和耐藥性。結(jié)果 共檢測出病原菌221株，其中革蘭陽性菌78株，構(gòu)成比為35.29%，主要為肺炎鏈球菌、金黃色葡萄球菌和表皮葡萄球菌；革蘭陰性菌143株，構(gòu)成比為64.71%，主要為肺炎克雷伯菌、大腸埃希菌和銅綠假單胞菌。肺炎鏈球菌對復(fù)方磺胺甲唑和紅霉素的耐藥率最高，為91.67%，對頭孢吡肟、萬古霉素的耐藥率最低，為0.00%。金黃色葡萄球菌對青霉素的耐藥率最高，為90.00%，對萬古霉素、頭孢吡肟、頭孢曲松和頭孢唑林的耐藥率最低，為0.00%。表皮葡萄球菌對紅霉素、青霉素和氨芐西林的耐藥率最高，為100.00%，對萬古霉素的耐藥率最低，為0.00%。肺炎克雷伯菌對亞胺培南的耐藥率最低，為0.00%，對氨芐西林的耐藥率最高，為97.96%；大腸埃希菌對美羅培南、亞胺培南的耐藥率最低，為0.00%，對氨芐西林的耐藥率最高，為94.29%；銅綠假單胞菌對舒巴坦的耐藥率最低，為3.85%，對氨芐西林、頭孢呋辛的耐藥率最高，為100.00%。結(jié)論 淮南新華醫(yī)療集團(tuán)新華醫(yī)院新生兒科重癥監(jiān)護(hù)室感染性疾病所分離的病原菌中以革蘭陰性菌為主，多數(shù)病原菌都具有較高的耐藥性，臨床藥敏檢測和細(xì)菌分析對于新生兒重癥監(jiān)護(hù)室的抗感染治療具有重要指導(dǎo)意義，能夠顯著減少耐藥菌的出現(xiàn)，提高治療效果。

Objective To explore the distribution and drug resistance of infectious diseases in the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital from 2016 to 2019. Methods The distribution and drug resistance of pathogens in the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital from January 2016 to April 2019 were retrospectively analyzed. Results A total of 221 strains of pathogenic bacteria were detected. Gram-positive bacteria bacteria were 78 strains (35.29%), and main of them were Streptococcus pneumonia, Staphylococcus aureus, and Staphylococcus epidermidis. Gram-negative bacteria bacteria were 143 strains (64.71%), and main of them were Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. The resistance rate of S. pneumoniae against compound sulfamethoxazole and erythromycin was the highest with 91.67%, and the resistance rate against cefepime and vancomycin was the lowest with 0.00%. The highest resistance rate of S. aureus against penicillin was the highest with 90.00%, and the lowest resistance rate against vancomycin, cefepime, ceftriaxone, and cefazolin was 0.00%. The resistance rate of S. epidermidis against erythromycin, penicillin, and ampicillin was the highest with 100.00%, and the resistance rate against vancomycin was 0.00%. The resistance rate of K. pneumoniae against imipenem was the lowest at 0.00%, and the highest rate of resistance against ampicillin was 97.96%. The lowest resistance rate of E. coli against meropenem and imipenem was highest at 0.00%, and the highest resistance rate to ampicillin was 94.29%. The lowest resistance rate of P. aeruginosa against sulbactam was 3.85%, and the highest resistance rate to ampicillin and cefuroxime was 100.00%. Conclusion The pathogens isolated from the intensive care unit of Department of Neonatology of Xinhua Medical Group Xinhua Hospital are mainly Gram-negative bacteria, and most of the pathogens have high drug resistance. Clinical drug sensitivity test and bacterial analysis for the anti-infective treatment of the intensive care unit of Department of Neonatology has important guiding significance, which can significantly reduce the emergence of drug-resistant bacteria and improve the therapeutic effect.

R978.1