目的 研究表沒食子兒茶素沒食子酸酯（EGCG）對高鹽引起的高血壓模型大鼠的降壓作用及作用機(jī)制。方法 大鼠隨機(jī)分為對照組、模型組和EGCG 50、100 mg/kg組，測定大鼠的大鼠平均動(dòng)脈壓，并采用Western blotting印跡法檢測大鼠下丘腦室旁核（PVN）中Toll樣受體4（TLR4）、核因子κB（NF-κB）p65、白細(xì)胞介素-1β（IL-1β）的水平；采用酶聯(lián)免疫吸附試驗(yàn)（ELISA）法檢測大鼠PVN中單核細(xì)胞趨化蛋白1（MCP-1）、腫瘤壞死因子α（TNF-α）和IL-6水平。結(jié)果 高鹽誘導(dǎo)的高血壓模型大鼠中TLR4表達(dá)量明顯增加（P<0.05）。EGCG 50、100 mg/kg顯著降低大鼠的平均動(dòng)脈壓（P<0.05），并明顯降低PVN中TLR4、NF-κB p65、IL-1β和TNF-α、IL-6、IL-1β水平（P<0.05）。結(jié)論 EGCG可降低高鹽誘導(dǎo)大鼠的高血壓，其機(jī)制可能與阻斷TLR4信號有關(guān)。

Objective To study the antihypertensive effect and mechanism of epigallocatechin gallate (EGCG) on hypertensive rats induced by high salt. Methods The rats were randomly divided into control group, model group, EGCG 50 and 100 mg/kg groups. The mean arterial pressure was recorded. TLR4, NF-κB p65, and IL-1β levels in PVN of rats treated with high salt were measured by Western blotting analysis. And the IL-1β, IL-6, TNF-α levels were detected by ELISA method. Results The expression of TLR4 increased significantly in hypertension rats induced by high salt (P<0.05). EGCG 50 and 100 mg/kg could significantly decrease the mean arterial pressure of rats (P<0.05), and could significantly reduce the expression of TLR4, NF-κB p65, IL-1β, TNF-α、IL-6, IL-1βTNF-α, IL-6, and IL-1β levels in PVN of rats treated with high salt. Conclusion EGCG can reduce blood pressure in hypertensive rats induced by high salt, and its mechanism may be related to blocking TLR4 signaling.

R965

河南省省部共建項(xiàng)目（SBGJ2018070）