目的 觀察升血靈顆粒聯合右旋糖酐鐵口服液治療小兒營養(yǎng)性缺鐵貧血的臨床效果。方法 2017年5月-2019年5月鄭州大學附屬兒童醫(yī)院治療的小兒營養(yǎng)性缺鐵貧血143例，將患兒隨機分成對照組（n=72）和治療組（n=71）。對照組患兒口服右旋糖酐鐵口服液，10 mL/次，1次/d。治療組在對照組用藥基礎上口服升血靈顆粒，一歲至三歲患兒10 g/次，三歲以上患兒15 g/次，3次/d。兩組患兒均連續(xù)治療30 d。觀察兩組患兒的臨床療效，比較兩組臨床癥狀消失時間、紅細胞血紅蛋白平均濃度（MCHC）、平均紅細胞容積（MCV）、血清鐵（SI）、血紅蛋白（Hb）。結果 治療后，對照組和治療組的總有效率分別是77.78%、92.96%，兩組比較差異有統(tǒng)計學意義（P<0.05）。和治療前比較，治療后兩組患兒MCHC、MCV、SI和Hb水平均顯著增高（P<0.05）；且治療后治療組患兒MCHC、MCV、SI和Hb水平顯著高于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。經過治療，治療組臨床癥狀消失時間顯著短于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。結論 升血靈顆粒聯合右旋糖酐鐵口服液治療小兒營養(yǎng)性缺鐵貧血具有較好的臨床療效，可有效提高機體血紅蛋白和血清鐵水平，調節(jié)鐵代謝和紅細胞狀況，促進患兒恢復，具有較好的臨床推廣應用。

Objective To observe the clinical effect of Shengxueling Granules combined with Iron Dextran Oral Solution in treatment of nutritional iron deficiency anemia in children. Methods 143 Children with nutritional iron deficiency anemia treated in Children's Hospital Affiliated to Zhengzhou University from May 2017 to May 2019 were randomly divided into control group (n=72) and treatment group (n=71). The children in control group were po administered with Iron Dextran Oral Solution, 10 mL/time, once daily. The children in treatment group were po administered with Shengxueling Granules on the basis of the control group, aged one to three years old received 10 g/time, and children over three years old received 15 g/time, 3 times daily. All patients were treated for 30 days. The clinical efficacy in two groups was observed. After treatment, the disappearance time of clinical symptoms, MCHC, MCV, SI, and Hb were compared. Results The total effective rate was 77.78% in the control group and 92.96% in the treatment group, and there were differences between two groups (P<0.05). After treatment, MCHC, MCV, SI and Hb levels were significantly higher in the two groups than before treatment (P<0.05). After treatment, MCHC, MCV, SI and Hb levels in the treatment group were significantly higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of clinical symptom in the treatment group was significantly shorter than that in the control group, and the difference between the two groups was statistically significant (P<0.05). Conclusion Shengxueling Granules combined with Iron Dextran Oral Solution has good clinical effect in treatment of nutritional iron deficiency anemia in children, and can effectively improve hemoglobin and serum iron levels, and also can regulate iron metabolism and red blood cell status, and promote the recovery of children, which has a certain clinical application value.

R973

河南省醫(yī)學科技攻關計劃項目（2018020618）