目的 分析安兒寧顆粒聯(lián)合乳糖酸紅霉素治療小兒上呼吸道感染的臨床效果。方法 選取2017年3月—2019年2月鄭州大學(xué)附屬兒童醫(yī)院治療的上呼吸道感染患兒137例，隨機(jī)分成對照組（n=68）和治療組（n=69）。對照組靜脈滴注注射用乳糖酸紅霉素，25 mg/kg溶于250 mL生理鹽水，1次/d。治療組在對照組治療基礎(chǔ)上口服安兒寧顆粒，1～5歲患兒3 g/次，5歲以上6 g/次，3次/d。兩組患兒均治療7 d。觀察兩組的臨床療效，比較兩組臨床癥狀消失時(shí)間、血清炎性因子的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別是72.06%、94.20%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組咳嗽、咽痛、發(fā)熱和流鼻涕等臨床癥狀消失時(shí)間明顯短于對照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。與治療前相比，治療后兩組患者腫瘤壞死因子-α（TNF-α）、白介素-1β（IL-1β）、白介素-10（IL-10）指標(biāo)均明顯降低（P<0.05）；且治療后治療組患者TNF-α、IL-1β和IL-10指標(biāo)明顯低于對照組，兩組比較差異具有顯著統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 安兒寧顆粒聯(lián)合乳糖酸紅霉素治療小兒上呼吸道感染具有較好的臨床療效，可快速緩解患兒咳嗽、咽痛、發(fā)熱和流鼻涕等臨床癥狀，改善機(jī)體炎癥反應(yīng)水平，具有較好的臨床療效。

Objective To analyze the clinical effect of Anerning Granules combined with erythromycin lactobionate in treatment of upper respiratory tract infection in children. Methods 137 Children with upper respiratory tract infection treated in Children's Hospital of Zhengzhou University from March 2017 to February 2019 were selected and randomly divided into control group (n=68) and treatment group (n=69). The control group was iv administered with Erythromycin Lactobionate for injection, 25 mg/kg was dissolved in normal saline 250 mL, once daily. The treatment group was po administered with Anerning Granules on the basis of the control group, 3 g/time for children aged 1 to 5 years old, 6 g/time for children over 5 years old, 3 times/daily. All children were treated for 7 days. The clinical efficacy in two groups was observed, and the disappearance time of clinical symptoms and the changes of serum inflammatory factors in the two groups were compared. Results The total effective rates in the control and treatment group were 72.06%, 94.20%, respectively, and there were differences between two groups (P<0.05). The disappearance time of clinical symptoms such as cough, sore throat, fever and runny nose in the treatment group was significantly shorter than that in the control group, and there were differences between two groups (P<0.05). The levels of TNF-α, IL-1β, and IL-10 were significantly reduced in both groups after treatment compared with before treatment. After treatment, the indicators of TNF-α, IL-1β, and IL-10 in the treatment group were significantly lower than those in the control group, and the differences between the two groups were statistically significant (P<0.05). Conclusion Anerning Granules combined with erythromycin lactobionate has good clinical effect in treatment of upper respiratory tract infection in children, and can quickly relieve the clinical symptoms of cough, sore throat, fever and runny nose, and improve the level of inflammatory response, which has a certain clinical application value.

R974

河南省2019年科技發(fā)展計(jì)劃項(xiàng)目（192102310073）