目的 探討丹參川芎嗪注射液聯(lián)合羥苯磺酸鈣分散片治療糖尿病視網(wǎng)膜病變的臨床療效。方法 選取2018年8月—2019年12月收治的92例糖尿病視網(wǎng)膜病變患者作為研究對象，所有患者按照隨機(jī)數(shù)字表法分為對照組和治療組，每組各46例。對照組口服羥苯磺酸鈣分散片，0.5 g/次，3次/d。治療組患者在對照組基礎(chǔ)上靜脈滴注丹參川芎嗪注射液，5 mL/次，1次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的視力指標(biāo)和視網(wǎng)膜血流動力學(xué)指標(biāo)。結(jié)果 治療后，治療組患者的總有效率（93.48%）比對照組（78.26%）高，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的視力值明顯升高，視野平均缺損指數(shù)、視野灰度值明顯降低（P<0.05）；治療后治療組的視力值比對照組高，視野平均缺損指數(shù)、視野灰度值比對照組低（P<0.05）。治療后，兩組眼動脈、視網(wǎng)膜中央動脈的峰值血流速度（PSV）明顯升高，阻力指數(shù)（RI）明顯降低（P<0.05）；治療后治療組的眼動脈、視網(wǎng)膜中央動脈的PSV比對照組高，RI比對照組低（P<0.05）。結(jié)論 丹參川芎嗪注射液聯(lián)合羥苯磺酸鈣分散片治療糖尿病視網(wǎng)膜病變具有較好的臨床療效，能改善視力狀況和眼部血流動力學(xué)水平，具有良好的臨床研究價值。

Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Calcium Dobesilate Dispersible Tablets in treatment of diabetic retinopathy. Methods Patients (92 cases) with diabetic retinopathy in the Fifth Affiliated Hospital of Zhengzhou University from August 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Calcium Dobesilate Dispersible Tablets, 0.5 g/time, three times daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 5 mL/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and visual acuity and retinal hemodynamic parameters in two groups were compared. Results After treatment, the total effective rate of the treatment group (93.48%) was higher than that of the control group (78.26%), and the difference was statistically significant (P<0.05). After treatment, the visual acuity values of two groups were significantly increased, but visual field average defect index and visual field gray value were significantly decreased (P<0.05). After treatment, the visual acuity value of the treatment group was higher than that of the control group, but visual field average defect index and visual field gray value were lower than those in the control group (P<0.05). After treatment, the PSV of ophthalmic artery and central retinal artery in the two groups were significantly increased, but the RI of ophthalmic artery and central retinal artery in the two groups were significantly decreased (P<0.05). After treatment, the PSV of ophthalmic artery and central retinal artery in the treatment group was higher than that in the control group, and RI of ophthalmic artery and central retinal artery in the treatment group was lower than that in the control group (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Calcium Dobesilate Dispersible Tablets has clinical curative effect in treatment of diabetic retinopathy, can improve visual acuity and ocular hemodynamics, which has good clinical research value.

R977

河南省醫(yī)學(xué)科技攻關(guān)計劃省部共建項目（sb201903012）