目的 探討蒲地藍(lán)消炎口服液聯(lián)合西帕依固齦液治療牙齦炎的臨床療效。方法 選取2018年5月—2019年11月在河南大學(xué)賽思口腔醫(yī)院接受治療的108例牙齦炎患者當(dāng)作研究對象，按照隨機(jī)數(shù)字表法將全部患者分為對照組和治療組，每組各54例。對照組含漱西帕依固齦液，3 mL/次，含漱3 min，5次/d。治療組在對照組患者治療的基礎(chǔ)上口服蒲地藍(lán)消炎口服液，10 mL/次，3次/d。兩組患者均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的患者牙周指標(biāo)菌斑指數(shù)（PLI）、齦溝出血指數(shù)（SBI）、牙齦指數(shù)（GI）、齦溝液中C反應(yīng)蛋白（CRP）、前列腺素E₂（PGE₂）、白細(xì)胞介素-6（IL-6）、白細(xì)胞介素-1β（IL-1β）水平和疼痛程度。結(jié)果 治療后，治療組患者的總有效率（92.59%）高于對照組（77.78%），差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的PLI、SBI、GI評分均低于治療前，且治療組PLI、SBI、GI評分低于對照組（P<0.05）。治療后，兩組的CRP、PGE₂、IL-6、IL-1β水平明顯低于治療前（P<0.05）；治療后治療組的CRP、PGE₂、IL-6、IL-1 β水平比對照組低（P<0.05）。治療后，兩組患者的VAS評分明顯降低（P<0.05），且治療組患者VAS評分較對照組降低的更明顯（P<0.05）。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合西帕依固齦液可有效提高牙齦炎的療效，改善牙周癥狀，減輕牙周組織的炎癥反應(yīng)，降低疼痛程度，且安全性較好，具有重要臨床研究價值。

Objective To investigate the clinical effect of Pudilan Xiaoyan Oral Liquid combined with Xipayi Guyin Mouth Rinse in treatment of gingivitis. Methods Patients (108 cases) with gingivitis in SATH Hospital of Stomatology Henan University from May 2018 to November 2019 were randomly divided into control and treatment groups, and each group had 54 cases. Patients in the control group were gargle administered with Xipayi Guyin Mouth Rinse, 3 mL/time, gargle for 3 min, five times daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes (PLI, SBI, and GI) and the levels of inflammatory factor CRP, PGE₂, IL-6 and IL-1β in two groups were compared. Results After treatment, the total effective rate in the treatment group (92.59%) was higher than that in the control group (77.78%), and the difference was statistically significant (P<0.05). After treatment, the scores of PLI, SBI, and GI in the two groups were significantly decreased (P<0.05), and the scores of PLI, SBI, and GI in the treatment group were lower than those in the control group (P<0.05). After treatment, the levels of CRP, PGE₂, IL-6 and IL-1β in the two groups were significantly decreased (P<0.05), and the levels of inflammatory factors in the treatment group were lower than those in the control group (P<0.05). After treatment, VAS scores in the two groups was significantly decreased (P<0.05), and VAS scores in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Xipayi Guyin Mouth Rinse has clinical curative effect in treatment of gingivitis, can improve the periodontal symptoms, reduce the inflammatory reaction of periodontal tissue, reduce the degree of pain, with good safety, which has important clinical research value.

R988.2

河南省醫(yī)學(xué)科技攻關(guān)計劃項目（2018020857）