[關(guān)鍵詞]
[摘要]
目的 探討固腎安胎丸聯(lián)合烯丙雌醇治療先兆流產(chǎn)的臨床效果。方法 選取2016年6月—2018年12月天津市東麗區(qū)東麗醫(yī)院收治的例先兆流產(chǎn)患者120,隨機(jī)分成對照組(60例)和治療組(60例)。對照組口服烯丙雌醇片,1片/次,3次/d。治療組在對照組基礎(chǔ)上口服固腎安胎丸,1袋/次,3次/d。兩組連續(xù)治療14 d。觀察兩組患者臨床療效,同時比較治療前后兩組患者主癥緩解時間,血清孕酮(P)、人絨毛膜促性腺激素β-亞基(β-HCG)、糖類抗原125(CA125)、妊娠相關(guān)血漿蛋白A(PAPP-A)和血管內(nèi)皮生長因子(VEGF)水平,子宮螺旋動脈血流動力學(xué)參數(shù)。結(jié)果 治療后,對照組臨床有效率為75.00%,顯著低于治療組的90.00%,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,治療組陰道出血、腰酸脹痛及下腹墜痛的緩解時間均顯著短于對照組(P<0.05)。治療后,兩組血清P、β-HCG、PAPP-A及VEGF濃度均顯著升高(P<0.05),而CA125含量均顯著下降(P<0.05);且治療組以上各項血清學(xué)標(biāo)志物的改善效果顯著好于對照組(P<0.05)。治療后,兩組子宮螺旋動脈血流動力學(xué)參數(shù)值均顯著降低(P<0.05),且治療組比對照組下降更為明顯(P<0.05)。結(jié)論 固腎安胎丸聯(lián)合烯丙雌醇治療先兆流產(chǎn)有助于迅速緩解患者臨床癥狀,維持正常妊娠,整體療效確切,且安全可靠。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Gushen Antai Pills combined with allylestrenol in treatment of threatened abortion. Methods Patients (120 cases) with threatened abortion in Tianjin Dongli District, Dongli Hospital from June 2016 to December 2018 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were po administered with Allylestrenol Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Gushen Antai Pills on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the relief time of main symptom, the serum level of P, β-HCG, CA125, PAPP-A and VEGF, hemodynamic parameters of uterine spiral artery in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 75.00%, which was significantly lower than 90.00% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the relief time of vaginal bleeding, low back pain and lower abdomen falling pain in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum level of P, β-HCG, CA125, PAPP-A and VEGF in two groups was significantly increased (P<0.05), but the CA125 level was significantly decreased (P<0.05), and these serological markers in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the hemodynamic parameters of uterine spiral artery in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Gushen Antai Pills combined with allylestrenol in treatment of threatened abortion can relieve the clinical symptoms, maintain normal pregnancy, has overall effect, with safety and reliability.
[中圖分類號]
R984
[基金項目]
天津市衛(wèi)生和計劃生育委員會科研基金項目(2017kz043)