目的 觀察小兒肺咳顆粒聯(lián)合環(huán)酯紅霉素治療急性小兒支氣管炎的臨床療效。方法 選擇2018年6月—2019年6月在彭州市婦幼保健計劃生育中心就診的急性支氣管炎患兒216例，隨機分為對照組和治療組，每組各108例。對照組口服環(huán)酯紅霉素干混懸劑，10～15 mg/kg，1次/12 h；治療組在對照組基礎(chǔ)上口服小兒肺咳顆粒，1歲以下患兒2 g/次、1～4歲患兒3 g/次、5～8歲6 g/次，3次/d。兩組患兒均治療7 d。觀察兩組患者臨床療效，同時比較治療前后兩組患者臨床癥狀改善情況，及超敏C反應蛋白（hs-CRP）、白細胞介素-10（IL-10）和IL-13水平。結(jié)果 治療后，對照組和治療組臨床有效率分別為75.93%和93.52%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組患者體溫恢復正常時間、咳嗽消失時間、肺部喘鳴音消失時間均較對照組明顯縮短（P<0.05）。治療后，兩組患者hs-CRP、IL-10和IL-13水平均明顯降低（P<0.05），且治療組患者的炎癥指標水平顯著低于對照組（P<0.05）。結(jié)論 小兒肺咳顆粒聯(lián)合環(huán)酯紅霉素治療急性小兒支氣管炎能夠快速緩解癥狀，改善炎癥指標，具有一定的臨床推廣應用價值。

Objective To observe the clinical efficacy of Xiaoer Feike Granules combined with erythromycin cyclocarbonate in treatment of acute bronchitis in children. Methods Children (216 cases) with acute bronchitis in Maternity Service Center of Pengzhou Maternal and Child Health Care Hospital from June 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 108 cases. Children in the control group were po administered with Erythromycin Cyclocarbonate for Suspension, 10-15 mg/kg, once every 12 h. Children in the treatment group were po administered with Xiaoer Feike Granules on the basis of the control group, 2 g/time for children under 1 year old, 3 g/time for children under 1-4 years old, 6 g/time for children under 5-8 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, the indicators of hs-CRP, IL-10 and IL-13 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 75.93% and 93.52% respectively, and there were differences between two groups (P<0.05). After treatment, the time of temperature returned to normal, cough disappearing and lung wheezing disappearing in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the level of hs-CRP, IL-10 and IL-13 in two groups was significantly decreased (P<0.05), and these inflammation indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xiaoer Feike Granules combined with erythromycin cyclocarbonate in treatment of acute bronchitis in children can quickly alleviate symptoms and improve inflammatory indicators, which has a certain clinical application value.

R974