目的 分析前列金丹片聯(lián)合多沙唑嗪片治療良性前列腺增生的臨床效果。方法 選擇2017年1月—2019年2月湖北省第三人民醫(yī)院收治的良性前列腺增生患者133例，隨機(jī)分成對(duì)照組（66例）和治療組（67例）。對(duì)照組口服甲磺酸多沙唑嗪片，2 mg/次，1次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服前列金丹片，6片/次，3次/d。兩組患者均治療3個(gè)月。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者前列腺特異抗原（PSA）、前列腺素E2（PGE2）、最大尿流量（Q_max）、膀胱殘余尿量（Ru）、國際前列腺癥狀評(píng)分（IPSS）和前列腺體積（PV）水平。結(jié)果 治療后，對(duì)照組臨床有效率為78.79%，顯著低于治療組的92.54%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者PSA、PGE2水平顯著降低（P<0.05），且治療組患者PSA、PGE2水平明顯比對(duì)照組低（P<0.05）。治療后，兩組患者Q_max水平顯著升高（P<0.05），而Ru、IPSS和PV水平均顯著降低（P<0.05），且治療組患者這些指標(biāo)改善效果明顯優(yōu)于對(duì)照組（P<0.05）。結(jié)論 前列金丹片聯(lián)合甲磺酸多沙唑嗪片治療良性前列腺增生，可改善PSA、PGE2水平，提高最大尿流量，減小膀胱殘余尿量和前列腺體積，具有較好的臨床效果。

Objective To analyze the clinical effect of Qianlie Jindan Tablets combined with doxazosin in treatiment of benign prostatic hyperplasia. Methods Patients (133 cases) with benign prostatic hyperplasia in the Third People's Hospital of Hubei Province from January 2017 to February 2019 were randomly divided into control (66 cases) and treatment (67 cases) groups. Patients in the control group were po administered with Doxazosin Mesylate Tablets, 2 mg/time, once daily. Patients in the treatment group were po administered with Qianlie Jindan Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the levels of PSA, PGE2, Q_max, Ru, IPSS and PV in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 78.79%, which was significantly lower than 92.54% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the levels of PSA, PGE2 in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the Q_max levels in two groups were significantly increased (P<0.05), but the Ru, IPSS and PV levels were significantly decreased (P<0.05), and these indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Qianlie Jindan Tablets combined with doxazosin in treatiment of benign prostatic hyperplasia can improve the levels of PSA and PGE2, increase the maximum urine flow, reduce the residual urine volume of bladder and prostate volume, and has good clinical effect.

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