近年來的研究報告顯示，在細胞水平和體外動物水平上，苯并咪唑類驅(qū)蟲藥物如甲苯咪唑、芬苯達唑具有抑制或輔助抑制癌癥的功能，個別患者使用后病程發(fā)展得到改善，相關(guān)的臨床試驗已經(jīng)注冊開展研究。主要介紹苯并咪唑類驅(qū)蟲藥甲苯咪唑和芬苯達唑可能具有的抗腫瘤作用機制，包括解聚微管蛋白、抑制葡萄糖的攝取和代謝、影響信號通路、抑制血管生成等途徑。

Recent studies suggest that antiparasitic medications with benzimidazole structure such as mebendazole and fenbendazole are effective in treatment of cancer, use as single drug or auxiliary drug at the cellular level and animal level in vitro. There are few case reports with objective or complete response. And a series of clinical trials have been proved to study the effectiveness. The possible anti-cancer mechanisms of antiparasitic medications with benzimidazole structure such as mebendazole and fenbendazole, including tubulin depolymerization, inhibition of uptake and metabolism of glucose, inhibition of signal transduction and angiogenesis inhibition are summarized in this paper.

R979.1

國家自然科學(xué)基金資助項目（21202125）