目的 探討癲癇寧片聯(lián)合丙戊酸鈉片治療顱腦外傷術(shù)后癲癇的臨床療效。方法 選擇2017年1月—2018年12月平煤神馬醫(yī)療集團總醫(yī)院收治的115例顱腦外傷所致癲癇患者作為研究對象，隨機將所有患者分為對照組（57例）和治療組（58例）。對照組患者口服丙戊酸鈉片，15 mg/（kg·d），分2～3次口服；治療組在對照組治療的基礎(chǔ)上口服癲癇寧片，4片/次，3次/d。兩組患者連續(xù)治療3個月。比較兩組患者的臨床療效，對癲癇發(fā)作情況、神經(jīng)遞質(zhì)、炎性因子、生化指標(biāo)進行比較分析。結(jié)果 治療后，對照組患者總有效率為77.19%，而治療組總有效率為89.65%，組間差異有顯著性（P<0.05）。治療后，兩組患者癲癇的發(fā)作次數(shù)、持續(xù)時間均持續(xù)降低（P<0.05），且治療組的發(fā)作次數(shù)、持續(xù)時間均明顯更低（P<0.05）。治療后，兩組患者腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）水平顯著下降（P<0.05），且治療后治療組患者的TNF-α、IL-6、CRP水平下降程度更多（P<0.05）。治療后，治療組患者一氧化氮（NO）水平、總抗氧化能力（T-AOC）顯著升高，丙二醛（MDA）水平明顯降低（P<0.05），且治療后治療組患者各指標(biāo)改善程度明顯高于對照組（P<0.05）。治療后，兩組患者γ-氨基丁酸（GABA）含量增加，谷氨酸（Glu）、天冬氨酸（Asp）水平明顯下降（P<0.05），而治療后治療組患者神經(jīng)遞質(zhì)含量改善程度明顯更高（P<0.05）。結(jié)論 癲癇寧片聯(lián)合丙戊酸鈉片治療顱腦外傷術(shù)后癲癇具有較好的臨床療效，可顯著降低患者的發(fā)作頻率和發(fā)作時間，提高機體的抗炎抗氧化能力，值得臨床推廣。

Objective To investigate the clinical study of Dianxianning Tablets combined with Sodium Valproate Tablets in treatment of epilepsy after craniocerebral trauma. Methods Patients (115 cases) with epilepsy after craniocerebral trauma in Pingmei Shenma Medical Group General Hospital from January 2017 to December 2018 were randomly divided into control group (57 cases) and treatment group (58 cases). Patients in the control group were po administered with Sodium Valproate Tablets, 15 mg/(kg·d), took orally in 2 — 3 times. Patients in the treatment group were po administered with Dianxianning Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and epileptic seizure, inflammatory factors, biochemical indicators, and neurotransmitter content in two groups were compared. Results After treatment, the total effective rate of the control group was 77.19%, while the total effective rate of the treatment group was 89.65%, and the difference between the groups was significant (P<0.05). After treatment, the frequency and duration of epilepsy in the two groups were significantly decreased (P<0.05), and the frequency and duration of epilepsy in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, and CRP in two groups were significantly decreased (P<0.05). And the levels of TNF-α, IL-6, and CRP in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, NO and T-AOC in two groups were significantly increased, but the levels of MDA in two groups were significantly decreased (P<0.05). And the inflammatory factors in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the GABA in two groups were significantly increased, but Glu and Asp in two groups were significantly decreased (P<0.05). And the biochemical indicators in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Dianxianning Tablets combined with Sodium Valproate Tablets has clinical curative effect in treatment of epilepsy after craniocerebral trauma, can significantly reduce the frequency and time of seizures, improve the body’s anti-inflammatory and anti-oxidation ability, which is worthy of clinical promotion.

R971