m)、腫瘤壞死因子-α(TNF-α)、白介素-6(IL-6)、可溶性細胞間黏附分子-1(sICAM-1)、谷胱甘肽過氧化物酶(GSH-Px)、總抗氧化能力(TAOC)、晚期氧化蛋白產(chǎn)物(AOPP)、血管內(nèi)皮生長因子(VEGF)和色素上皮細胞衍生因子(PEDF)水平。結(jié)果 治療后,對照組臨床有效率79.36%,顯著低于治療組的93.65%,兩組比較差異有統(tǒng)計學意義(P<0.05)。治療后,兩組CRV、RI、PI、TNF-α、sICAM-1、IL-6、OPP和EGF明顯降低(P<0.05),而PSV、EDV、Vm、SH-Px、TAOC和EDF較治療前明顯升高(P<0.05),且治療后治療組這些指標水平明顯優(yōu)于對照組(P<0.05)。結(jié)論 杞菊地黃丸聯(lián)合銀杏葉提取物注射液治療糖尿病視網(wǎng)膜病變患者具有良好的臨床療效,可抑制炎癥反應、氧化應激反應、血管新生,具有一定的臨床推廣應用價值。;Objective To explore the clinical effect of Qiju Dihuang Pills combined with extract of Extract of Ginkgo Biloba Leaves Injection in treatment of nonproliferative diabetic retinopathy. Methods Patients (126 cases) with nonproliferative diabetic retinopathy in Kaifeng Hospital of TCM from January 2018 to June 2019 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were iv administered with Extract of Ginkgo Biloba Leaves Injection, 70 mg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Qiju Dihuang Pills on the basis of the control group, 8 pills/time, three times daily. 2 weeks for a course of treatment, each course interval of 2 d, and patients in two groups were treated for 2 courses of treatment. After treatment, the clinical efficacy was evaluated, and the levels of PSV, EDV, Vm, TNF-α, sICAM-1, IL-6, GSH-Px, TAOC AOPP and PEDF in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.36%, which was significantly lower than 93.65% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the levels of CRV, RI PI, TNF-α, sICAM-1, IL-6, OPP and EGF in two groups were significantly decreased (P<0.05), but the levels of PSV, EDV, Vm, SH-Px, TAOC and EDF were significantly increased (P<0.05), and these indexes levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Qiju Dihuang Pills combined with Extract of Ginkgo Biloba Leaves Injection in treatment of nonproliferative diabetic retinopathy has a good clinical effect,can inhibit inflammatory reaction, oxidative stress reaction, angiogenesis, which has a certain clinical application value."/>

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首頁 > 過刊瀏覽>2020年第35卷第6期 >2020,35(6):1176-1180. DOI:10.7501/j.issn.1674-5515.2020.06.025
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杞菊地黃丸聯(lián)合銀杏葉提取物治療非增殖期糖尿病視網(wǎng)膜病變的臨床研究

Clinical study on Qiju Dihuang Pills combined with extract of ginkgo biloba leaves in treatment of nonproliferative diabetic retinopathy

發(fā)布日期:2020-06-20