目的 研究齒痛消炎靈顆粒聯(lián)合鹽酸米諾環(huán)素軟膏治療急性智齒冠周炎的臨床療效。方法 選取2016年8月—2019年8月在漯河醫(yī)學(xué)高等專科學(xué)校第二附屬醫(yī)院治療的80例急性智齒冠周炎患者，所有患者隨機分為對照組和治療組，每組各40例。對照組患者口腔清洗后將鹽酸米諾環(huán)素軟膏注滿患部牙周袋內(nèi)，1次/周；治療組在對照組基礎(chǔ)上口服齒痛消炎靈顆粒，1袋/次，3次/d。兩組患者持續(xù)治療4周。觀察兩組的臨床療效，比較兩組患者的視覺模擬評分法（VAS）評分、牙齦指數(shù)（GI）、臨床癥狀緩解時間、齦溝液因子白細胞介素-1（IL-1）、腫瘤壞死因子-α（TNF-α）和前列腺素E₂（PGE₂）水平。結(jié)果 治療后，對照組和治療組的總有效率分別為77.50%、92.50%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者VAS評分和GI均顯著降低（P<0.05）；且治療組VAS評分和GI降低較多（P<0.05）。治療后，治療組牙齒腫痛、張口受限、全身癥狀消失時間明顯短于對照組（P<0.05）。治療后，兩組患者IL-1、TNF-α和PGE₂水平顯著降低（P<0.05）；并且治療組齦溝液因子水平降低較多（P<0.05）。結(jié)論 齒痛消炎靈顆粒聯(lián)合鹽酸米諾環(huán)素軟膏治療急性智齒冠周炎具有較好的治療效果，可緩解臨床癥狀，減少疼痛，降低齦溝液因子水平，值得在臨床上推廣應(yīng)用。

Objective To study the effect of Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment in treatment of acute pericoronitis of wisdom teeth. Methods Patients (80 cases) with acute pericoronitis of wisdom teeth in the Second Affiliated Hospital of Luohe Medical College from August 2016 to August 2019 were randomly divided into control and treatment groups, and each group had 40 cases. After oral cleaning, the periodontal bags of patients in the control group were filled with Minocycline Hydrochloride Ointment, once weekly. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and VAS score, GI, clinical symptom remission time, levels of IL-1, TNF-α, and PGE2 in gingival crevicular fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.50% and 92.50%, respectively (P<0.05). After treatment, the VAS score and GI in the two groups were significantly decreased (P<0.05), and the VAS score and GI in the treatment group were significantly lower than those in the control group (P<0.05).After treatment, the disappearance time of swelling and pain, mouth opening limitation and systemic symptoms in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of IL-1, TNF-α, and PGE₂ in the two groups were significantly decreased (P<0.05), and the gingival crevicular fluid factors in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Chitong Xiaoyanling Granules combined with Minocycline Hydrochloride Ointment has clinical curative effect in treatment of acute pericoronitis of wisdom teeth, can alleviate clinical symptoms, reduce pain, and reduce the factor level of gingival crevicular fluid, which is worthy of clinical application.

R988.2