目的 探討安宮牛黃丸聯(lián)合更昔洛韋膠囊治療重癥病毒性腦炎的臨床療效。方法 選取2017年2月-2020年2月在南陽(yáng)南石醫(yī)院治療的62例重癥病毒性腦炎患兒為研究對(duì)象，將所有患兒隨機(jī)分為對(duì)照組和治療組，每組各31例。對(duì)照組患兒口服更昔洛韋膠囊，1 000 mg/次，3次/d。治療組患兒在對(duì)照組基礎(chǔ)上口服安宮牛黃丸，1次/d，3歲以下：1/4丸/次，3~6歲：1/2丸/次，6~10歲：1丸/次。兩組患兒接受治療時(shí)間為2周。觀察兩組患兒的臨床療效，比較兩組臨床癥狀消失時(shí)間、血清神經(jīng)元特異性烯醇化酶（NSE）和S100β蛋白水平。結(jié)果 治療后，治療組總有效率為93.55%，較對(duì)照組的80.65%顯著較高（P<0.05）。治療后，治療組患兒退熱時(shí)間、癥狀控制時(shí)間、精神癥狀改善時(shí)間、抽搐控制時(shí)間、意識(shí)清醒時(shí)間顯著短于對(duì)照組（P<0.05）。治療后，兩組患兒血清NSE、S100β蛋白水平顯著降低（P<0.05），且治療組血清NSE、S100β蛋白水平降低程度較大P<0.05）。結(jié)論 安宮牛黃丸聯(lián)合更昔洛韋膠囊治療重癥病毒性腦炎療效顯著，可改善患兒的臨床癥狀，降低血清因子水平，值得臨床推廣。

Objective To investigate the clinical efficacy of Angong Niuhuang Pills combined with Ganciclovir Capsules in treatment of severe viral encephalitis. Methods Children (62 cases) with severe viral encephalitis in Nanshi Hospital of Nanyang from February 2017 to February 2020 were randomly divided into control and treatment groups, and each group had 31 cases. Children in the control group were po administered with Ganciclovir Capsules, 1 000 mg/time, three times daily. Children in the treatment group were po administered with Angong Niuhuang Pills on the basis of the control group, under 3 years old:1/4 pill/time, 3-6 years old:1/2 pill/time, 6-10 years old:1 pill/time, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom relief times, and the serum levels of NSE and S100β protein in two groups were compared. Results After treatment, the effective rate of the treatment group was 93.55%, which was significantly higher than that of the control group (80.65%) (P<0.05). After treatment, the antipyretic time, symptom control time, mental symptom improvement time, convulsion control time, and conscious time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the serum levels of NSE and S100β protein of the two groups were significantly decreased (P<0.05), and after treatment, the serum levels of NSE and S100β protein in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Angong Niuhuang Pills combined with Ganciclovir Capsules has clinical curative effect in treatment of severe viral encephalitis, can improve the clinical symptoms of children and reduce serum factor levels, which is worthy of clinical application.

R971

河南省科技攻關(guān)項(xiàng)目（201701034）