目的 探討疏風(fēng)解毒膠囊聯(lián)合氨茶堿注射液治療慢性支氣管炎急性發(fā)作的臨床療效。方法 選擇2018年1月-2020年1月天津市寧河區(qū)醫(yī)院收治的88例慢性支氣管炎急性發(fā)作患者，隨機(jī)分為對照組（44例）和治療組（44例）。對照組靜脈滴注氨茶堿注射液，0.25 g加到15%葡萄糖溶液250 mL中，3次/d。治療組在對照組治療的基礎(chǔ)上口服疏風(fēng)解毒膠囊，4粒/次，3次/d。兩組均連續(xù)治療1周。觀察兩組的臨床療效，比較兩組患者治療前后第一秒用力呼氣量（FEV1）、用力肺活量（FVC）、最大呼氣流速（PEF）、血氧分壓（pO₂）、二氧化碳分壓（pCO₂）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）及白細(xì)胞介素-8（IL-8）水平的變化情況。結(jié)果 治療組的臨床總有效率為95.45%，對照組是77.27%，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后FEV1、FVC及PEF均明顯比治療前高（P<0.05），同時(shí)治療組治療后FEV1、FVC及PEF均明顯比對照組高（P<0.05）。兩組治療后pO₂均明顯高于治療前，pCO₂均明顯低于治療前（P<0.05），同時(shí)治療組治療后pO₂明顯高于對照組，pCO₂明顯低于對照組（P<0.05）。兩組治療后血清TNF-α、CRP及IL-8水平均明顯比治療前低（P<0.05），同時(shí)治療組治療后血清TNF-α、CRP及IL-8水平均明顯比對照組低（P<0.05）。兩組治療期間均無嚴(yán)重的不良反應(yīng)發(fā)生。結(jié)論 疏風(fēng)解毒膠囊聯(lián)合氨茶堿注射液治療慢性支氣管炎急性發(fā)作的臨床療效顯著，能夠明顯提升肺功能，改善血?dú)庵笜?biāo)，降低血清炎性因子水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical efficacy of Shufeng Jiedu Capsules combined with Aminophylline Injection in treatment of acute exacerbation of chronic bronchitis. Methods 88 Patients with acute exacerbation of chronic bronchitis admitted to Tianjin Ninghe District Hospital from January 2018 to January 2020 in Tianjin Ninghe District Hospital were randomly divided into control group (44 cases) and treatment group (44 cases). The control group was iv administered with Aminophylline Injection, 0.25 g added to 15% Glucose Solution250 mL, three times daily. The treatment group was po administered with Shufeng Jiedu Capsules, 4 grains/time, three times daily. All patients were treated for 1 week. The clinical efficacy in two groups were observed, and the changes of FEV1, FVC, PEF, pO₂, pCO₂, TNF-α, CRP, and IL-8 before and after in two groups were compared. Results The total effective rate was 95.45% in the treatment group and 77.27% in the control group, and there were differences between two groups (P<0.05). After treatment, FEV1, FVC and PEF in both groups were significantly higher than those before treatment (P<0.05), and FEV1, FVC and PEF in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, pO₂ was significantly higher than that before treatment, but pCO₂ was significantly lower than that before treatment (P<0.05). After treatment, pO₂ in the treatment group was higher than that in the control group, but pCO₂ was significantly lower than the control group, and there were differences between two groups (P<0.05). No serious adverse reactions occurred during the treatment in both groups. Conclusions Shufeng Jiedu Capsules combined with Aminophylline Injection has a significant clinical effect in treatment of acute exacerbation of chronic bronchitis, and can significantly improve lung function, improve blood gas index, and reduce the level of serum inflammatory factors, which has a certain clinical application value.

R974

天津市自然科學(xué)基金項(xiàng)目（16JCYBJC24185）