目的 探討野木瓜片聯(lián)合苯妥英鈉片治療三叉神經(jīng)痛的臨床療效。方法 選擇2018年5月-2019年5月在天津醫(yī)科大學(xué)第二醫(yī)院治療的三叉神經(jīng)痛患者84例，根據(jù)用藥的差別分為對照組（42例）和治療組（42例）。對照組口服苯妥英鈉片，初始劑量100 mg/次，3次/d，連續(xù)3 d后，根據(jù)病情逐漸減少劑量，最終維持40 mg/d。治療組在對照組基礎(chǔ)上口服野木瓜片，1.60 g/次，3次/d。兩組患者均治療4周。觀察兩組患者臨床療效，同時比較治療前后兩組患者VAS、PSQI和LSI-B評分，及血清C反應(yīng)蛋白（CRP）、血漿P物質(zhì)（SP）、降鈣素基因相關(guān)肽（CGRP）、白細胞介素-1β（IL-1β）和5-羥色胺（5-HT）水平。結(jié)果 治療后，對照組臨床有效率為80.95%，顯著低于治療組的97.62%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。經(jīng)治療，兩組患者VAS評分和PSQI評分顯著降低（P<0.05），而LSI-B評分顯著升高（P<0.05），且治療組患者這些評分明顯好于對照組（P<0.05）。經(jīng)治療，兩組患者血清CRP、SP、CGRP和IL-1β水平明顯降低（P<0.05），而5-HT水平明顯升高（P<0.05），且治療組患者的血清學(xué)指標水平明顯優(yōu)于對照組（P<0.05）。結(jié)論 野木瓜片聯(lián)合苯妥英鈉片治療三叉神經(jīng)痛能有效改善患者疼痛癥狀，可有效改善機體炎癥水平，改善患者失眠情況及提高患者生活質(zhì)量。

Objective To explore the clinical effect of Yemugua Tablets combined with phenytoin in treatment of trigeminal neuralgia. Methods Patients (84 cases) with trigeminal neuralgia in the Second Hospital of Tianjin Medical University from May 2018 to May 2019 were randomly divided into control (42 cases) and treatment (42 cases) groups. Patients in the control group were po irrigation administered with Phenytoin Sodium Tablets, the initial dose was 100 mg/time, three times daily, then gradually reduced dose according to illness after 3 d, and the maintenance dose was 40 mg/d. Patients in the treatment group were po administered with Yemugua Tablets on the basis of the control group, 1.6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, the scores of VAS, PSQI and LSI-B, and the levels of CRP, SP, CGRP, IL-1β and 5-HT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.95%, which was significantly lower than 97.62% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the scores of VAS and PSQI in two groups were significantly decreased (P<0.05), but the LSI-B scores were significantly increased (P<0.05), and these scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the level of CRP, SP, CGRP, IL-1β in two groups was significantly decreased (P<0.05), but the 5-HT level was significantly increased (P<0.05), and these serological indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Yemugua Tablets combined with phenytoin in treatment of trigeminal neuralgia can effectively improve the pain symptoms,, improve insomnia and the quality of life of patients.

R971