目的 研究胰膽舒顆粒聯(lián)合注射用蘭索拉唑治療急性胰腺炎的臨床療效。方法 選取2018年12月-2019年12月鄭州大學(xué)附屬洛陽(yáng)中心醫(yī)院收治的100例急性胰腺炎患者為研究對(duì)象，將所有患者隨機(jī)分為對(duì)照組和治療組，每組各50例。對(duì)照組患者靜脈注射注射用蘭索拉唑，30 mg溶于0.9%氯化鈉注射液100 mL中，2次/d。治療組在對(duì)照組基礎(chǔ)上口服胰膽舒顆粒，10 g/次，3次/d。兩組患者持續(xù)治療10 d。觀察兩組患者臨床療效，比較兩組的臨床癥狀緩解時(shí)間、胰腺炎床旁嚴(yán)重度指數(shù)（BISAP）評(píng)分、血清學(xué)指標(biāo)、血清炎性因子水平。結(jié)果 治療后，治療組總有效率94.00%，顯著高于對(duì)照組的80.00%（P<0.05）。治療后，治療組排氣恢復(fù)正常時(shí)間、腹水消失時(shí)間、血淀粉酶恢復(fù)正常時(shí)間、排氣恢復(fù)正常時(shí)間、腹痛消失時(shí)間、尿淀粉酶恢復(fù)正常時(shí)間明顯短于對(duì)照組（P<0.05）。治療后，兩組胰腺炎床旁嚴(yán)重度指數(shù)（BISAP）評(píng)分顯著降低（P<0.05）；并且治療組BISAP評(píng)分降低較明顯（P<0.05）。治療后，兩組血清淀粉酶（AMS）、脂肪酶（LPS）水平顯著降低（P<0.05）；并且治療組血清AMS、LPS水平明顯低于對(duì)照組（P<0.05）。治療后，兩組患者血清腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）和白細(xì)胞介素-6（IL-6）水平顯著降低（P<0.05）；并且治療組血清TNF-α、CRP和IL-6水平明顯低于對(duì)照組（P<0.05）。結(jié)論 胰膽舒顆粒聯(lián)合注射用蘭索拉唑治療急性胰腺炎具有較好的治療效果，能夠改善臨床癥狀，降低血清AMS和LPS、炎性因子水平，值得在臨床上推廣應(yīng)用。

Objective To study the effect of Yidanshu Granules combined with Lansoprazole for injection in treatment of acute pancreatitis. Methods Patients (100 cases) with acute pancreatitis in Luoyang Central Hospital Affiliated to Zhengzhou University from December 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Lansoprazole for injection, 30 mg added into 0.9% sodium chloride injection 100 mL, twice daily. Patients in the treatment group were po administered with Yidanshu Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptom, the BISAP score, the serological index, and the serum inflammatory factor in two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.00%, which was significantly higher than that of the control group (80.00%) (P<0.05). After treatment, the recovery time of exhaust, ascites, blood amylase, exhaust, abdominal pain and urine amylase in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the BISAP scores of two groups was significantly decreased (P<0.05), and BISAP score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the serum levels of AMS and LPS in the two groups were significantly decreased (P<0.05), and the serum levels of AMS and LPS in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of TNF-α, CRP, and IL-6 in the two groups were significantly decreased (P<0.05), and the serum inflammatory factor levels in the treatment group were lower than those in the control group (P<0.05). Conclusion Yidanshu Granules combined with Lansoprazole for injection has clinical curative effect in treatment of acute pancreatitis, can improve clinical symptoms, reduce serum levels of AMS, LPS, and inflammatory factors, which is worthy of clinical application.

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