目的 觀察西地碘含片聯(lián)合聚維酮碘治療牙周炎的臨床效果。方法 選擇2017年1月-2018年12月在河南省省直第二醫(yī)院治療的型牙周炎患者149例，隨機(jī)分成對(duì)照組（74例）和治療組（75例）。對(duì)照組牙周袋沖洗聚維酮碘溶液。治療組在對(duì)照組治療基礎(chǔ)上含服西地碘含片，1.5 mg/次，3次/d。兩組患者均連續(xù)治療2周。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者C反應(yīng)蛋白（CRP）、可溶性黏附分子1（sICAM-1）、白介素-10（IL-10）、牙菌斑指數(shù)（PLI）、牙齦指數(shù)（GI）和齦溝出血指數(shù)（SBI）水平。結(jié)果 治療后，對(duì)照組臨床有效率為79.76%，顯著低于治療組的89.76%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者CRP、sICAM-1、PLI、GI和SBI水平均顯著降低（P<0.05），而IL-10水平均顯著升高（P<0.05），且治療后治療組患者這些指標(biāo)水平改善效果明顯優(yōu)于對(duì)照組（P<0.05）。結(jié)論 西地碘含片聯(lián)合聚維酮碘治療牙周炎，可明顯改善患者臨床癥狀，緩解機(jī)體炎癥反應(yīng)水平，改善牙周情況。

Objective To observe the clinical effect of Cydiodine Buccal Tablets combined with povidone iodine in Treatment of periodontitis. Methods Patients (149 cases) with periodontitis in the Second Hospital Directly under the Authority of Henan from January 2017 to December 2018 were randomly divided into control (74 cases) and treatment (75 cases) groups. Patients in the control group were periodontal pocket irrigation administered with Povidone Iodine Solution. Patients in the treatment group were po administered with Cydiodine Buccal Tablets on the basis of the control group, 1.5 mg/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the level of CRP, sICAM-1, IL-10, PLI, GI and SBI in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.76%, which was significantly lower than 89.76% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the level of CRP, sICAM-1, PLI, GI and SBI in two groups was significantly decreased (P<0.05), but the IL-10 level was significantly increased (P<0.05), and these indicators in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Cydiodine Buccal Tablets combined with povidone iodine in Treatment of periodontitis can obviously improve the clinical symptoms, relieve the level of inflammatory reaction, and improve the gum condition.

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