目的 分析2017-2019年中國(guó)人民解放軍聯(lián)勤保障部隊(duì)第九八八醫(yī)院特殊使用級(jí)抗菌藥物的使用情況，為規(guī)范化管理和臨床合理用藥提供參考依據(jù)。方法 對(duì)2017-2019年中國(guó)人民解放軍聯(lián)勤保障部隊(duì)第九八八醫(yī)院特殊使用級(jí)抗菌藥物的使用數(shù)量、銷售金額、用藥頻度（DDDs）、使用強(qiáng)度（AUD）、日均費(fèi)用（DDC）及藥品排序比（B/A）等指標(biāo)進(jìn)行回顧性統(tǒng)計(jì)和分析。結(jié)果 2017-2019年，特殊使用級(jí)抗菌藥物的總銷售金額呈逐年遞增趨勢(shì)，其中亞胺培南西司他丁（進(jìn)口）連續(xù)3年排名第1位。DDDs值基本呈增長(zhǎng)趨勢(shì)，其中亞胺培南西司他?。ㄟM(jìn)口）和伏立康唑的DDDs值排序連續(xù)3年變化明顯。亞胺培南西司他丁（國(guó)產(chǎn)）和伏立康唑的AUD連續(xù)3年不斷上升。2018年之后，亞胺培南西司他?。ㄟM(jìn)口）的AUD明顯下降，其他藥物的AUD基本保持不變。各藥物的DDC基本保持不變。進(jìn)口亞胺培南西司他丁、伏立康唑和兩性霉素B的B/A連續(xù)3年變化明顯且偏離1.00較大，其他藥物的B/A均接近1.00。結(jié)論 中國(guó)人民解放軍聯(lián)勤保障部隊(duì)第九八八醫(yī)院特殊使用級(jí)抗菌藥物的臨床應(yīng)用基本合理，但個(gè)別藥物使用存在問(wèn)題。醫(yī)院應(yīng)繼續(xù)加強(qiáng)管理，采取必要措施，促進(jìn)藥物合理使用，有效遏制和減緩細(xì)菌耐藥性的產(chǎn)生。

Objective To analyze the utilization of special class antimicrobial drugs in No.988 Hospital of PLA from 2017 to 2019, in order to provide reference for standard management and rational use of drugs in clinic. Methods The utilization of special class antimicrobial drugs in No.988 Hospital of PLA from 2017 to 2019 was analyzed statistically in respect of amounts, consumption sum, defined daily doses(DDDs), antibiotics use density(AUD), defined daily cost(DDC), and drug sequence ratio(B/A). Results From 2017 to 2019, the total sales amount of antibacterial agents in special use level showed an increasing trend year by year, with imports imipenem and cilastatin ranking the first for three consecutive years. The DDDs value was basically increasing, the order of DDDs of imports imipenem and cilastatin and voriconazole had changed significantly for three consecutive years. AUD of domestic imipenem and cilastatin and voriconazole kept rising. After 2018, AUD of imports imipenem and cilastatin significantly decreased, the other drugs basically remained unchanged. The ranking of DDC for each drug was basically stable. The B/A value of imports imipenem and cilastatin, voriconazole and amphotericin B had changed significantly for three consecutive years and had a large deviation from 1.00, and the others were close to 1.00. Conclusion The application of antibacterial agents in special use level in No.988 Hospital of PLA is basically reasonable, but there are still some problems with individual drugs. The hospital should continue to strengthen management and have more effort to promote rational use of special class antimicrobial drugs, so as to effectively curb and slow down bacterial resistance.

R978.1