目的 了解天津市兒童醫(yī)院口服抗組胺藥的使用情況，為臨床藥品管理和合理用藥提供參考。方法 收集天津市兒童醫(yī)院2017-2019年門診藥房口服抗組胺藥品的相關(guān)數(shù)據(jù)信息，統(tǒng)計藥品用藥金額、用藥頻度（DDDs）、日均費(fèi)用（DDC），并分析其變化趨勢。結(jié)果 2018、2019年口服抗組胺藥的使用量和用藥金額相對平穩(wěn)，但相對于2017年的使用量和用藥金額則均有大幅提升，第1代抗組胺藥的用藥金額占比不到全部抗組胺藥的1%，3年來，抗組胺藥的用藥頻度（DDDs）排在第1位的藥品是鹽酸左西替利嗪片，日均費(fèi)用（DDC）最高的藥品是氯雷他定糖漿。結(jié)論 天津市兒童醫(yī)院抗組胺藥的使用量和用藥頻率與患兒年齡特征和兒童過敏性疾病的發(fā)病率密切相關(guān)，其臨床應(yīng)用基本合理，同時應(yīng)及時了解臨床用藥現(xiàn)狀，規(guī)范管理，合理用藥。

Objective To understand the use of oral antihistamines in Tianjin Children's Hospital, and provide a reference for clinical drug management and rational drug use. Methods The relevant data of oral antihistamine drugs were collected in outpatient pharmacies of Tianjin Children's Hospital from 2017 to 2019, and sales amount, frequency of drug use (DDDs), and daily average drug cost (DDC) were statistically counted to analyze their changes. Results The use and amount of oral antihistamines in 2018 and 2019 were relatively stable, but compared to 2017, the use and amount of drugs were significantly increased. The amount of first-generation antihistamines accounted for less than 1% of the total antihistamines. For the past three years, the drug with the highest frequency of application of antihistamines has been Levoctirizine Hydrochloride Tablets, the drug with the highest average daily cost of applying antihistamines was Loratadine Syrup. Conclusion The amount and frequency of antihistamines in Tianjin Children's Hospital are closely related to the age characteristics of children and the incidence of allergic diseases in children. Its clinical application is basically reasonable. At the same time, the current status of clinical medication should be timely understood and strived to achieve standardized management and rational use of medication.

R977