目的 探討天麻鉤藤飲聯(lián)合奧美沙坦治療肝陽(yáng)上亢型原發(fā)性高血壓的臨床效果。方法 選取2016年6月-2019年6月在上海市光華中西醫(yī)結(jié)合醫(yī)院就診的肝陽(yáng)上亢型原發(fā)性高血壓患者150例，隨機(jī)分為對(duì)照組和治療組，每組各75例。對(duì)照組口服奧美沙坦酯片，20~40 mg/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服天麻鉤藤飲，每天1劑，分早晚兩次服用。兩組患者治療8周。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者血壓變化和中醫(yī)證候積分。結(jié)果 治療后，治療組總有效率是94.67%，顯著高于對(duì)照組84.00%（P<0.05）。治療后，兩組患者收縮壓和舒張壓明顯下降（P<0.05），且治療組比對(duì)照組下降更明顯（P<0.05）。治療后，兩組患者中醫(yī)證候積分均明顯下降（P<0.05），且治療組比對(duì)照組下降更明顯（P<0.05）。結(jié)論 天麻鉤藤飲聯(lián)合奧美沙坦治療肝陽(yáng)上亢型原發(fā)性高血壓患者更具優(yōu)勢(shì)，且安全性高。

Objective To explore the clinical effects of Tianma Gouteng Decoction combined with olmesartan in treatment of essential hypertension of liver-yang syndrome. Methods Patients (150 cases) with essential hypertension of liver-yang syndrome in Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine from June 2016 to June 2019 were randomly divided into control and treatment groups, and each group had 75 cases. Patients in the control group were po administered with Olmesartan Medoxomil Tablets, 20-40 mg/time, once daily. Patients in the treatment group were po administered with Tianma Gouteng Decoction on the basis of the control group, morning and evening twice a dose of drug. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood pressure and TCM symptom scores in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 94.67%, significantly higher than that of the control group (84.00%, P<0.05). After treatment, the systolic and diastolic blood pressure in two groups were significantly decreased (P<0.05), and the blood pressure in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the TCM symptom scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than that in the control group (P<0.05). Conclusion Tianma Gouteng Decoction combined with olmesartan in treatment of essential hypertension of liver-yang syndrome has more advantages, and high safety.

R972

上海市長(zhǎng)寧區(qū)青年中醫(yī)醫(yī)師培養(yǎng)計(jì)劃項(xiàng)目（2015CNQNZY003）