目的 觀察復(fù)方氫溴酸右美沙芬聯(lián)合頭孢羥氨芐治療小兒支氣管炎的臨床效果。方法 選擇2017年8月-2019年10月在洛陽市婦幼保健院治療的小兒支氣管炎患兒147例，隨機(jī)分為對(duì)照組（74例）和治療組（73例）。對(duì)照組口服頭孢羥氨芐顆粒，每次15~20 mg/kg，2次/d；治療組在對(duì)照組的基礎(chǔ)上口服復(fù)方氫溴酸右美沙芬糖漿，2~3歲3 mL/次，4~6歲4 mL/次，6~9歲5 mL/次，3次/d。兩組患兒均連續(xù)治療7 d。觀察兩組患者臨床療效，同時(shí)比較治療前后兩組患者炎性因子半胱氨酰白三烯（CysLTs）、呼出氣一氧化氮（FeNO）和嗜酸性細(xì)胞陽離子（ECP）水平，及臨床癥狀消失時(shí)間。結(jié)果 治療后，對(duì)照組臨床有效率為78.38%，顯著低于治療組的94.52%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組CysLTs、FeNO和ECP水平均顯著降低（P<0.05），且治療組明顯低于對(duì)照組（P<0.05）。治療后，治療組臨床癥狀消失時(shí)間明顯比對(duì)照組短（P<0.05）。結(jié)論 復(fù)方氫溴酸右美沙芬聯(lián)合頭孢羥氨芐治療小兒支氣管炎，可快速改善患兒臨床癥狀，緩解機(jī)體炎癥反應(yīng)，臨床療效較好。

Objective To observe the clinical effect of compound dextromethorphan hydrobromide combined with cefadroxil in treatment of bronchitis in children. Methods Children (147 cases) with bronchitis in Luoyang Maternal and Child Health Hospital from August 2017 to October 2019 were randomly divided into control (74 cases) and treatment (73 cases) groups. Children in the control group were po administered with Cefadroxil Granules, once 15-20 mg/kg, twice daily. Children in the treatment group were po administered with Compound Dextromethorphan Hydrobromide Syrup on the basis of the control group, 3 mL/time for 2-3 years old, 4 mL/time for 4-6 years old, 5 mL/time for 6-9 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, the inflammatory factors level of CysLTs, FeNO and ECP, and the disappearance time of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 78.38%, which was significantly lower than 94.52% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the inflammatory factors level of CysLTs, FeNO and ECP in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the disappearance time of clinical symptoms in the treatment group was significantly earlier than that in the control group (P<0.05). Conclusion Compound dextromethorphan hydrobromide combined with cefadroxil in treatment of bronchitis in children can quickly improve the clinical symptoms, relieve the inflammatory reaction, and has good clinical effect.

R974

國(guó)家衛(wèi)生計(jì)生委醫(yī)藥衛(wèi)生科技發(fā)展研究中心資助項(xiàng)目（W2015EAE046）