目的 研究糖尿病視網(wǎng)膜病變患者內(nèi)眼術(shù)前結(jié)膜囊菌群分布以及藥敏分析特點(diǎn)，為糖尿病視網(wǎng)膜病變患者術(shù)后眼炎的預(yù)防提供臨床指導(dǎo)。方法 收集463例糖尿病視網(wǎng)膜病變眼病患者結(jié)膜囊分泌物行細(xì)菌培養(yǎng)、鑒定及藥敏分析。結(jié)果 463例糖尿病視網(wǎng)膜病變患者共取樣518份棉拭子接種，518份樣本中檢出菌株286例，檢出率55.21%，其中革蘭陽(yáng)性菌檢出233株占81.47%，其中表皮葡萄球菌163株（56.99%），棒狀桿菌其次27株（9.44%），金黃色葡萄球菌20株（6.99%）；革蘭陰性菌檢出53株占18.53%，其中鮑曼不動(dòng)桿菌20株（6.99%），粘質(zhì)沙雷菌12株（4.20%），大腸埃希菌10株（3.50%）；表皮葡萄球菌、金黃色葡萄球菌對(duì)紅霉素、頭孢他啶、慶大霉素耐藥，對(duì)萬古霉素、左氧氟沙星等喹諾酮類藥物敏感；除紅霉素、妥布霉素、諾氟沙星外，棒狀桿菌對(duì)所檢測(cè)抗生素均較為敏感；鮑曼不動(dòng)桿菌對(duì)哌拉西林耐藥。結(jié)論 糖尿病視網(wǎng)膜病變患者結(jié)膜囊分泌物細(xì)菌培養(yǎng)鑒定及藥敏分析為術(shù)前結(jié)膜囊無菌化合理用藥的關(guān)鍵，對(duì)術(shù)后眼內(nèi)炎癥的預(yù)防至關(guān)重要。

Objective To study the distribution of the conjunctival sac and the characteristics of drug sensitivity analysis in patients with diabetes, and to provide clinical guidance for the prevention of postoperative ophthalmia in diabetic patients. Methods Bacterial culture, identification and drug sensitivity analysis of conjunctival sac secretion from 463 patients with diabetic retinopathy were performed. Results A total of 518 cotton swabs were inoculated in 463 patients with diabetic retinopathy, 286 were detected in 518 samples, the detection rate was 55.21%, of which 233 were Gram-positive, 81.47% were detected, 163 were Staphylococcus epidermidis (56.99%), followed by 27 were Corynebacterium (9.44%) and 20 were Staphylococcus aureus (6.99%), 53 were Gram-negative, 18.53% were detected, 20 were Acinetobacter baumannii (6.99%), 12 were Corynegeria (4.20%), 10 were Staphylococcus escherichia coli (3.50%); Bacteria, Staphylococcus aureus, resistant to erythromycin, ceftazidime, gentamicin, sensitive to vancomycin, levofloxacin and other quinolones; except erythromycin, Corynebacterium is more sensitive to the tested antibiotics; Acinetobacter baumannii is resistant to Piperacillin. Conclusion The identification and drug sensitivity of bacterial culture for diabetic retinopathy is the key to the rational use of the conjunctival sac and the prevention of postoperative endophthalmitis.

R978.1