柚皮素是一種具有多種生物活性的天然黃酮類化合物。但較低的水溶性和生物利用度限制了其臨床應(yīng)用。近年來(lái)國(guó)內(nèi)外關(guān)于柚皮素納米脂質(zhì)體、納米乳、納米混懸劑、納米凝膠、納米固體分散體和納米粒在提高溶解度、改善吸收等方面取得了一定進(jìn)展。通過(guò)查閱國(guó)內(nèi)外文獻(xiàn)，對(duì)近年來(lái)柚皮素納米新劑型研究進(jìn)行綜述，為其后續(xù)研發(fā)提供必要的思路和參考。

Naringenin is a kind of natural flavonoid compound with multiple active activities. However, the application of naringenin is limited by its low water solubilility and inadequate bioavailability. In recent years, studies on naringenin preparation, including nanoliposome, nanoemulsion, nanosuspension, nanogel, nano-solid dispersion, and nanoparticles, have made some progress in improving the solubility and absorption at home and abroad. This paper summarizes the new formulations of naringenin, and provides necessary ideas and references for the future development.

R944

國(guó)家重點(diǎn)研發(fā)計(jì)劃中醫(yī)藥現(xiàn)代化研究重點(diǎn)專項(xiàng)（2018YFC1706700）；黑龍江省自然科學(xué)基金資助項(xiàng)目（H201472）