腎功能不全是由多種原因共同作用導(dǎo)致的機(jī)體酸堿失衡、水電解質(zhì)紊亂等。該疾病好發(fā)于老年群體，臨床癥狀主要表現(xiàn)為貧血、代謝性酸中毒、高血壓等，嚴(yán)重者可累及全身多個(gè)臟器組織。高尿酸血癥可進(jìn)一步導(dǎo)致老年腎功能不全疾病的發(fā)生，進(jìn)而加重腎功能損害，甚至痛風(fēng)。此外老年人常用降脂降壓、抗生素等藥物，更易引發(fā)因藥物引起的腎損害，故探討降尿酸藥物別嘌醇、非布司他、托匹司他、丙磺舒、苯溴馬隆、拉布立酶、培戈洛酶治療對老年腎功能不全患者腎功能的影響，以期為臨床治療提供參考。

Renal insufficiency is caused by a variety of reasons, which lead to acid-base imbalance of the body, water and electrolyte disorder and so on. The disease predisposes to the elderly. The main clinical symptoms are anemia, metabolic acidosis, hypertension, and so on. In severe cases, multiple organs and tissues of the body can be involved. Hyperuricemia can further lead to the occurrence of renal insufficiency in the elderly, and then aggravate the damage of renal function, even gout. In addition, medications such as lipid and blood pressure lowering and antibiotics are commonly used in the elderly, which are more likely to cause renal damage from drugs. This paper discusses the effects of uric acid lowering drugs, such as allopurinol, febuxostat, topista, probenecid, benzbromarone, labilise, and pegolose on renal function in elderly patients with renal insufficiency, in order to provide reference for clinical treatment.

R983