目的 探討清肺消炎丸聯(lián)合頭孢丙烯分散片治療兒童急性上呼吸道感染臨床療效。方法 選取2017年1月-2019年12月在天津市濱海新區(qū)中醫(yī)醫(yī)院治療的急性上呼吸道感染患兒109例，隨機(jī)分為對照組（54例）和治療組（55例）。對照組口服頭孢丙烯分散片，每次7.5 mg/kg，2次/d；治療組患兒在對照組基礎(chǔ)上口服清肺消炎丸，2~3歲患兒20丸/次，3~6歲30丸/次，6歲~12歲40丸/次，3次/d。兩組患兒療程7~14 d。觀察兩組患兒臨床療效，同時比較治療前后兩組患兒癥狀和體征，及血清降鈣素原（PCT）、白細(xì)胞介素-8（IL-8）、IL-4和半胱氨酰白三烯（CyslTs）水平。結(jié)果 治療后，治療組總有效率是90.91%，顯著高于對照組的70.37%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組體溫恢復(fù)正常時間、惡心咳嗽消失時間、咽痛消失時間、鼻塞流涕時間和咽部充血消失時間都明顯早于對照組（P<0.05）。治療后，兩組患兒血清PCT、1L-8、1L-4和CyslTs水平明顯降低（P<0.05），且治療組顯著低于對照組（P<0.05）。結(jié)論 清肺消炎丸聯(lián)合頭孢丙烯分散片治療兒童急性上呼吸道感染效果突出，明顯改善患兒癥狀和體征，降低血清炎性因子水平。

Objective To investigate the curative effect of Qingfei Xiaoyan Pills combined with cefprozil in treatment of acute upper respiratory tract infection in children. Methods Children (109 cases) with acute upper respiratory tract infection in Binhai New Area Hospital of TCM Tianjin from January 2017 to December 2019 were randomly divided into control (54 cases) and treatment (55 cases) groups. Children in the control group were po administered with Cefprozil Dispersible Tablets, 7.5 mg/kg, twice daily. Children in the treatment group were po administered with Qingfei Xiaoyan Pills on the basis of the control group, 20 pills/time for 2-3 years old, 30 pills/time for 3-6 years old, 40 pills/time for 6-12 years old, three times daily. Children in two groups were treated for 7-14 d. After treatment, the clinical efficacy was evaluated, and the symptoms and signs, the serum levels of PCT, 1L-8, 1L-4, and CyslTs in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 90.91%, significantly higher than that of the control group (70.37%), and there were differences between two groups (P<0.05). After treatment, the time of temperature recovering normal, the disappearance time of nausea and cough, sore throat, nasal congestion and runny nose and hyperemia of pharynx in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the serum levels of PCT, 1L-8, 1L-4, and CyslTs in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qingfei Xiaoyan Pills combined with cefprozil in treatment of acute upper respiratory tract infection in children is effective, can obviously improve the symptoms and signs and reduce the inflammatory factors.

R985

天津市衛(wèi)生計(jì)生委、天津市中醫(yī)藥管理局中醫(yī)、中西醫(yī)結(jié)合科研課題（2017095）