目的 探討金花清感顆粒聯(lián)合帕拉米韋治療兒童流行性感冒的臨床療效。方法 選取2017年1月-2020年1月在天津市寧河區(qū)醫(yī)院進行治療的206例流行性感冒患兒為研究對象，根據(jù)就診順序分為對照組（103例）和治療組（103例）。對照組靜脈滴注帕拉米韋氯化鈉注射液，10 mg/kg，1次/d。治療組在對照組基礎上口服金花清感顆粒，1袋/次，2次/d。兩組連續(xù)治療5 d后進行效果對比。結(jié)果 經(jīng)治療，治療組總有效率是98.06%，顯著高于對照組82.52%（P<0.05）。經(jīng)治療，治療組高熱、咳嗽、咽痛、鼻塞等臨床癥狀消失時間顯著短于對照組（P<0.05）。經(jīng)治療，兩組血清超敏C反應蛋白（hs-CRP）、白細胞計數(shù)（WBC）、中性粒細胞百分比（NEU）、白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平均顯著下降（P<0.05）；且治療后，治療組這些血清學指標顯著低于對照組（P<0.05）。結(jié)論 金花清感顆粒聯(lián)合帕拉米韋治療流行性感冒患兒具有較好的臨床療效，不僅能促進臨床癥狀改善，還可降低機體炎癥因子水平，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Jinhua Qinggan Granules combined with pramivir in treatment of children with influenza. Methods 206 Children with influenza who were treated in Tianjin Ninghe Hospital from January 2017 to January 2020 were selected as the research objects, and they were divided into control group (103 cases) and treatment group (103 cases) according to the order of treatment. Patients in the control group were iv administered with Peramivir and Sodium Chloride Injection, 10 mg/kg, once daily. Patients in the treatment group were po administered with Jinhua Qinggan Granules on the control group, 1 bag/time, twice daily. The two groups were compared after 5 d of continuous treatment. Results After treatment, the total effective rate in the treatment group was 98.06%, significantly higher than that in the control group (82.52%) (P<0.05). After treatment, the disappearance time of clinical symptoms such as high fever, cough, sore throat and nasal obstruction in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, WBC, NEU, IL-6, and TNF-α significantly decreased in both groups (P<0.05). After treatment, these serological indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jinhua Qinggan Granule combined with peramivir has good clinical effect in treatment of children with influenza, and can not only promote the improvement of clinical symptoms, but also reduce the level of inflammatory factors in the body, which has a certain clinical application value.

R985

黑龍江省衛(wèi)生計生委科研課題（2016-155）