目的 探討腎衰寧顆粒聯(lián)合前列地爾注射液治療慢性腎衰竭的臨床療效。方法 選取2017年6月-2019年6月在河南科技大學(xué)第一附屬醫(yī)院就診的180例慢性腎衰竭患者作為研究對(duì)象，根據(jù)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組各90例。對(duì)照組靜脈滴注前列地爾注射液，10 μg加入10 mL生理鹽水中靜脈滴注，1次/d。治療組在對(duì)照組基礎(chǔ)上溫水沖服腎衰寧顆粒，5 g/次，3次/d。兩組連續(xù)治療21 d。觀察兩組的臨床療效，比較兩組的腎功能指標(biāo)、血清因子水平。結(jié)果 治療后，治療組的總有效率為77.78%，對(duì)照組為64.44%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的血肌酐（Scr）、尿素氮（BUN）、胱抑素C（Cys-C）、24 h尿蛋白水平明顯降低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組的Scr、BUN、Cys-C、24 h尿蛋白水平低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的轉(zhuǎn)化生長(zhǎng)因子β₁（TGF-β₁）、結(jié)締組織生長(zhǎng)因子（CTGF）、纖維連接蛋白（FN）水平均明顯降低，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組的TGF-β₁、CTGF、FN水平低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 腎衰寧顆粒聯(lián)合前列地爾注射液可提高慢性腎衰竭的療效，能改善腎功能，延緩腎小球纖維化進(jìn)程，且安全性較好。

Objective To investigate the clinical effect of Shenshuaining Granules combined with Alprostadil Injection in treatment of chronic renal failure. Methods Patients (180 cases) with chronic renal failure in the First Affiliated Hospital of Henan University of Science and Technology from June 2017 to June 2019 were randomly divided into control and treatment groups, and each group had 90 cases. Patients in the control group were iv administered with Alprostadil Injection, 10 μg added into normal saline 10 mL, once daily. Patients in the treatment group were po administered with Shenshuaining Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 21 d. After treatment, the clinical efficacies were evaluated, and renal function index and serum factor level in two groups were compared. Results After treatment, the total effective rate of the treatment group was 77.78%, and that of the control group was 64.44%, and the difference was statistically significant (P<0.05). After treatment, the levels of Scr, BUN, Cys-C, and 24 h urinary protein in two groups were significantly lower than those in the control group (P<0.05). After treatment, the levels of Scr, BUN, Cys-C, and 24 h urinary protein in the treatment group were lower than those in the control group with statistical significance (P<0.05). After treatment, the levels of TGF-β₁, CTGF, and FN in two groups were significantly lower than those in the control group (P<0.05). After treatment, the levels of TGF-β₁, CTGF, and FN in the treatment group were lower than those in the control group with a statistically significant difference (P<0.05). Conclusion Shenshuaining Granules combined with Alprostadil Injection has clinical curative effect in treatment of chronic renal failure, can improve renal function, delay the progression of glomerular fibrosis with good safety.

R983

河南省醫(yī)學(xué)科技攻關(guān)計(jì)劃項(xiàng)目（2018020280）