目的 統(tǒng)計(jì)云浮市人民醫(yī)院2017-2019年抗菌藥物不良反應(yīng)（ADR）發(fā)生例數(shù)，探討ADR發(fā)生的原因。方法 回顧性分析2017-2019年云浮市人民醫(yī)院上報(bào)廣東省藥品不良反應(yīng)監(jiān)測(cè)中心的抗菌藥物相關(guān)的ADR的病例，統(tǒng)計(jì)發(fā)生ADR的患者的一般情況，包括年齡、性別、ADR發(fā)生的時(shí)間、ADR的類型、ADR涉及的具體表現(xiàn)等。結(jié)果 2017-2019年本院共上報(bào)抗菌藥物ADR 97例，共涉及11種抗菌藥物，包括頭孢菌素類、喹諾酮類、碳青霉烯類等抗菌藥物，其中嚴(yán)重ADR 8例，上報(bào)的ADR給藥途徑絕大部分為靜脈給藥，經(jīng)停藥對(duì)癥治療后基本上都能好轉(zhuǎn)，僅1例未見好轉(zhuǎn)。結(jié)論 作為本地區(qū)最大的三甲醫(yī)院，收治患者眾多，抗菌藥物使用量大，但本院的抗菌藥物ADR上報(bào)例數(shù)相對(duì)少于國內(nèi)同樣規(guī)模的醫(yī)院，抗菌藥物引起的ADR對(duì)人體可造成不同程度的損傷，ADR值得引起重視，應(yīng)加強(qiáng)ADR的上報(bào)工作。

Objective To count the number of cases of adverse drug reactions (ADR) of antibacterial drugs in Yunfu City People's Hospital from 2017-2019, to explore the causes of ADR. Methods A retrospective analysis of 97 cases of antimicrobial-related ADR reported to the Guangdong Adverse Reaction Monitoring Center from 2017 to 2019. The general situation of patients with ADR including:age, gender, and time of ADR, the type of ADR, the specific manifestations involved in ADR, etc. Results From 2017 to 2019, Yunfu City People's Hospital reported a total of 97 cases of antimicrobial ADR, involving a total of 11 antimicrobial drugs, including cephalosporins, quinolones, carbapenem and other antimicrobial drugs, including 8 cases of serious ADR. Most of the adverse drug administration routes were intravenous administration, which can basically be improved after symptomatic treatment of withdrawal. Only 1 case had not improved. Conclusion As the largest top three level of first-class hospital in the region, there are many patients admitted and the use of antimicrobial drugs is large, but the number of reported antimicrobial drug ADR in the hospital is relatively less than that of domestic hospitals of the same size. Caused different degrees of damage, ADR should be concerned, and the reporting of ADR should be strengthened.

R969.3