血小板減少癥是卡鉑的劑量限制性毒性。根據(jù)腎小球濾過率（GFR）的變量改變影響游離卡鉑曲線下面積（AUC）與所給劑量的線性關(guān)系，提出了卡鉑按AUC給藥的計算方法。目前臨床上使用Calvert公式計算卡鉑劑量，用Cockcroft-Gault公式計算出的肌酐清除率（CrCl）來代替GFR。但是Cockcroft-Gault公式在臨床應(yīng)用中也存在一些局限性。對卡鉑的給藥劑量計算策略進(jìn)行綜述，找到最佳劑量的計算方法，以供卡鉑在臨床合理用藥和個體化治療中參考。

Thrombocytopenia is the dose-limiting toxicity of carboplatin. According to the variable changes of glomerular filtration rate (GFR), it affects the linear relationship between free carboplatin AUC and the given dose. A calculation method for carboplatin administration based on AUC is proposed. At present, the Calvert formula is used to calculate the carboplatin dose in clinical practice, and the creatinine clearance (CrCl) calculated by the Cockcroft-Gault equation is used to replace GFR. However, the Cockcroft-Gault equation has some limitations in clinical application. This article reviews the calculation strategy of carboplatin dosage, and the calculation method of the optimal dose was found, which can provide reference for carboplatin in clinical rational use and individualized treatment.

R962

國家重點研發(fā)計劃精準(zhǔn)醫(yī)學(xué)研究重點專項項目（2017YFC0909900）