+、CD4+、CD4+/CD8+均顯著升高,但對照組CD8+顯著升高,治療組CD8+顯著降低(P<0.05);治療后治療組細胞免疫功能優(yōu)于對照組(P<0.05)。治療組不良反應發(fā)生率低于對照組(5.00%vs 20.00%)(P<0.05)。結論 燈臺葉顆粒聯(lián)合環(huán)酯紅霉素治療類百日咳綜合征的臨床療效較好,可緩解患兒臨床癥狀及體征,降低炎性因子,安全性較高,具有一定的臨床推廣應用價值。;Objective To investigate the effect of Dengtaiye Granules combined with cycloester erythromycin in treatment of pertussis like syndrome. Methods A total of 120 children with pertusse like syndrome admitted to Children's Hospital Affiliated to Zhengzhou University from April 2018 to April 2020 were randomly divided into control group and treatment group, with 60 children in each group. Children in the control group were po administered with Erythromycin Cyclic 11,12-Carbonate For Suspension, 15 mg/(kg∙d), once every 12 h. Children in the treatment group were po administered with Dengtaiye Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and clinical symptoms, signs remission time and hospital stay time, serum inflammatory factors and cellular immune function indicators were compared between two groups. Results After treatment, the total effective rate of the treatment group was 95.00%, significantly higher than that of the control group (78.33%, P<0.05). After treatment, the disappearance time of rhonchus in lung, relief time of dyspnea, relief time of spastic cough and hospital stay in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, serum levels of interleukin-6 (IL-6), interleukin-4 (IL-4), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were significantly decreased in both groups (P<0.05). After treatment, the level of serum inflammatory factors in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ were significantly increased in both groups, but CD8+ was significantly increased in the control group and significantly decreased in the treatment group (P<0.05). After treatment, the cellular immune function of the treatment group was better than that of the control group (P<0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group (5.00% vs 20.00%) (P<0.05). Conclusion Dengtaiye Granules combined with cycloester erythromycin has good clinical effect in treatment of pertussis like syndrome, and can alleviate the clinical symptoms and signs of children, and also can reduce inflammatory factors with a high safety, which has certain clinical application value."/>