目的 探討復(fù)明膠囊聯(lián)合聚乙二醇滴眼液治療白內(nèi)障術(shù)后干眼癥的臨床療效。方法 選取2017年8月—2019年12月濮陽市人民醫(yī)院收治的93例白內(nèi)障術(shù)后干眼癥患者（142眼）。根據(jù)信封法將所有患者分為對照組（46例，69眼）和治療組（47例，73眼）。對照組患者滴眼聚乙二醇滴眼液，3次/d。治療組在對照組治療的基礎(chǔ)上口服復(fù)明膠囊，5粒/次，3次/d。兩組連續(xù)治療8周。觀察兩組的臨床療效，比較兩組淚液腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）、超敏C反應(yīng)蛋白（hs-CRP）、角膜熒光素染色（FL）評分、淚液分泌試驗（Sit）長度、淚膜破裂時間（BUT）和干眼癥狀評分。結(jié)果 治療后，治療組總有效率為89.04%，顯著高于對照組的73.91%，差異有顯著性意義（P<0.05）。治療后，兩組FL評分下降，BUT、Sit長度升高（P<0.05）；且治療組FL評分低于對照組，BUT、Sit長度高于對照組（P<0.05）。治療4、8周后，兩組干眼癥狀評分均顯著下降（P<0.05），并且治療組干眼癥狀評分低于同期對照組（P<0.05）。治療后，兩組淚液TNF-α、IL-6、hs-CRP水平均明顯下降（P<0.05），并且治療組淚液TNF-α、IL-6、hs-CRP水平低于對照組（P<0.05）。結(jié)論 復(fù)明膠囊聯(lián)合聚乙二醇滴眼液治療白內(nèi)障術(shù)后干眼癥療效確切，可有效改善其臨床癥狀，有效降低淚液TNF-α、IL-6、hs-CRP水平，安全性較好。

Objective To investigate the clinical effect of Fuming Capsules combined with Polyethylene Glycol Eye Drops in treatment of dry eye after cataract surgery. Methods Patients (93 cases, 142 eyes) with dry eye after cataract surgery in Puyang People’s Hospital from August 2017 to December 2019 were enrolled in this study. According to envelope method, patients were randomly divided into the control group (46 cases, 69 eyes) and the treatment group (47 cases, 73 eyes). Patients in the control group were given Polyethylene Glycol Eye Drops, three times daily. Patients in the treatment group were po administered with Fuming Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and TNF-α, IL-6, and hs-CRP of tears, FL score, Sit long, and BUT in two groups were compared. Results After treatment, the total effective rate of the treatment group was 89.04%, which was significantly higher than that of the control group (73.91%), and the difference was significant (P<0.05). After treatment, FL score of two groups was decreased, but BUT and Sit length of two groups were increased (P<0.05). And FL score of the treatment group was lower than that of the control group, but BUT and Sit length of the treatment group were higher than that of the control group (P<0.05). After treatment for 4 and 8 weeks, the dry eye symptom scores of two groups were significantly decreased (P<0.05), and the dry eye symptom scores of the treatment group were lower than those of the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, and hs-CRP in two groups were significantly decreased (P<0.05), and the levels of TNF-α, IL-6, and hs-CRP in the treatment group were lower than those in the control group (P<0.05). Conclusion Fuming Capsules combined with Polyethylene Glycol Eye Drops is effective in treatment of dry eye after cataract surgery. It can effectively improve the clinical symptoms and effectively reduce the levels of TNF-α, IL-6, and hs-CRP in tears, with good safety.

R988.1

河南省醫(yī)學(xué)科技攻關(guān)計劃項目（201603282）